Meclizine dihydrochloride

Cat. No. 4245 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Human pregnane X receptor agonist; H₁ antagonist

别名： Meclozine

化学名： 1-[(4-Chlorophenyl)phenylmethyl]4-[(3-methylphenyl)methyl]piperazine dihydrochloride

纯度： ≥99% (HPLC)

引用文献 (2)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Meclizine dihydrochloride

Meclizine dihydrochloride is a human pregnane X receptor (hPXR) agonist; it is a more potent activator of hPXR than rat PXR. Meclizine increases hPXR target gene expression in human hepatocyte primary cultures. It also acts as a histamine H₁ receptor antagonist. Meclizine attenuates mitochondrial respiration and increases glycolysis. The product inhibits rotenone-induced cell death in stem cell-derived dopaminergic neuronal culture and confers neuroprotection in models of polyglutamine (polyQ) toxicity.

化合物库 for Meclizine dihydrochloride

Meclizine dihydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Meclizine dihydrochloride

分子量	463.87
公式	C₂₅H₂₇ClN₂.2HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	1104-22-9
PubChem ID	64713
InChI Key	VCTHNOIYJIXQLV-UHFFFAOYSA-N
Smiles	CC1=CC(CN(CC4)CCN4C(C3=CC=C(Cl)C=C3)C2=CC=CC=C2)=CC=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Meclizine dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	23.19	50

制备储备液 for Meclizine dihydrochloride

以下数据基于产品分子量 463.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	4.31 mL	21.56 mL	43.12 mL
2.5 mM	0.86 mL	4.31 mL	8.62 mL
5 mM	0.43 mL	2.16 mL	4.31 mL
25 mM	0.09 mL	0.43 mL	0.86 mL

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产品说明书 for Meclizine dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Meclizine dihydrochloride

参考文献是支持产品生物活性的出版物。

et al (2010) Meclizine is Hum.Mol.Genet. 294 et al (2021) Pluripotent Stem Cell Reports

If you ht">Parada of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception. 102 PMID: 11182255

ht">Gohil neuroprotective in models of Huntington's disease. 20 PMID: 20977989

ht">Lau effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor. 336 PMID: 21131266

ht">Oosterveen stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinson's disease. PMID: 34678205 know of a relevant reference for Meclizine dihydrochloride, please let us know.

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关键词: Meclizine dihydrochloride, Meclizine dihydrochloride supplier, antihistamine, histaminergic, pregnane, x, receptors, pxr, hpxr, NR1|2, agonists, activators, neuroprotective, neuroprotectants, meclozine, mitochondrial, respiration, polyglutamine, polyQ, Huntington's, disease, Huntingtons, increases, glycolysis, Meclozine, Histamine, H1, Receptors, Pregnane, X, Receptor, Oxidative, Phosphorylation, 4245, Tocris Bioscience

2 篇 Meclizine dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Meclizine dihydrochloride 的部分引用包括：

Hong et al (2016) Meclizine-induced enhanced glycolysis is neuroprotective in Parkinson disease cell models. Sci Rep 6 25344 PMID: 27145922

Oosterveen et al (2021) Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinson's disease. Stem Cell Reports 16 2718 PMID: 34678205

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