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Pregnane X Receptors

Pregnane X receptors (PXRs) are nuclear receptors that regulate the expression of CYP3A genes, generating key enzymes involved in xenobiotic metabolism. PXRs also help regulate the induction of P-gp. PXRs are highly expressed in the liver, small intestine and colon.

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Background
Literature (1)
Gene Data

Pregnane X Receptor Agonists
Cat. No. Product Name / Activity
4245 Meclizine dihydrochloride
Human pregnane X receptor agonist; H1 antagonist
2969 SR 12813
Pregnane X receptor agonist

Related Targets

    Pregnane X receptors (PXRs) are nuclear receptors that regulate the expression of CYP3A genes, thus generating key enzymes involved in xenobiotic metabolism. PXRs also help regulate the induction of P-gp. PXRs are highly expressed in the liver, small intestine and colon.

    Numerous ligands activate PXRs, including a range of xenobiotics such as dexamethasone and nifedipine, and naturally occurring steroids. PXR forms a non-permissive heterodimer with RXR receptors in order to bind the promoter and enhancer of the CYP3A4 gene.

    External sources of pharmacological information for Pregnane X Receptors :

      Literature for Pregnane X Receptors

      Tocris offers the following scientific literature for Pregnane X Receptors to showcase our products. We invite you to request* your copy today!

      *Please note that Tocris will only send literature to established scientific business / institute addresses.

      Retinoid Receptors Scientific Review

      Retinoid Receptors Scientific Review

      Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.

      Pregnane X Receptor Gene Data

      Gene Species Gene Symbol Gene Accession No. Protein Accession No.
      NR1I2 Human NR1I2 NM_003889 O75469
      Rat Nr1i2 NM_052980 Q3B7V1