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Submit ReviewParoxetine maleate
说明： Highly potent and selective 5-HT uptake inhibitor
化学名： (3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine maleate
纯度： ≥99% (HPLC)
生物活性 for Paroxetine maleate
Paroxetine maleate is a highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for α1-, α2- or β-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.
技术数据 for Paroxetine maleate
| 分子量 | 445.44 |
| 公式 | C19H20FNO3.C4H4O4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 64006-44-6 |
| PubChem ID | 6435921 |
| InChI Key | AEIUZSKXSWGSRU-QXGDPHCHSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.FC1=CC=C(C=C1)[C@@H]1CCNC[C@H]1COC1=CC2=C(OCO2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Paroxetine maleate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 44.54 | 100 | |
| DMSO | 44.54 | 100 |
制备储备液 for Paroxetine maleate
以下数据基于产品分子量 445.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.24 mL | 11.22 mL | 22.45 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.49 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
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产品说明书 for Paroxetine maleate
参考文献 for Paroxetine maleate
参考文献是支持产品生物活性的出版物。
Thomas et al (1987) Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor. Psychopharmacology 93 193 PMID: 2962217
Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305 PMID: 9400006
Bourin et al (2001) Paroxetine: a review. CNS Drug Rev. 7 25 PMID: 11420571
Fujishiro et al (2002) Comparison of the anticholin. effects of the serotonergic antidepressants, paroxetine, fluvox. and clomipramine. Eur.J.Pharmacol. 454 183 PMID: 12421645
If you know of a relevant reference for Paroxetine maleate, please let us know.
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关键词: Paroxetine maleate, Paroxetine maleate supplier, potent, selective, 5-HT, reuptake, inhibitors, inhibits, serotonin, inhibitor, transporters, SERT, 5-Hydroxytryptamine, monoamine, neurotransmitter, Transporters, 2141, Tocris Bioscience
7 篇 Paroxetine maleate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Paroxetine maleate 的部分引用包括：
Mathes et al (2013) The selective serotonin reuptake inhibitor parox. decreases breakpoint of rats engaging in a progressive ratio licking task for sucrose and qine solutions. Chem Senses 38 211 PMID: 23254343
Zhou et al (2019) A neural circuit for comorbid depressive symptoms in chronic pain. Nat Neurosci 22 1649 PMID: 31451801
Steiner et al (2015) Interaction of parox. with mitochondrial proteins mediates neuroprotection. J Neurosci 12 200 PMID: 25404050
Mathes and Spector (2014) Systemic modulation of serotonergic synapses via reuptake blockade or 5HT1A receptor antagonism does not alter perithreshold taste sensitivity in rats. Chem Senses 39 583 PMID: 25056731
Lazar et al (2015) Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway. Front Pharmacol 6 210 PMID: 26441665
Mathes and Spector (2011) The selective serotonin reuptake inhibitor parox. does not alter consummatory concentration-dependent licking of prototypical taste stimuli by rats. Chem Senses 36 515 PMID: 21422376
Huang et al (2009) Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. BMC Neurosci 29 13909 PMID: 19890001
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.