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Rilpivirine

Cat. No. 7684 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Non-nucleoside reverse transcriptase inhibitor
化学名： 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Rilpivirine

Rilpivirine is a potent diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). It has high antiviral activity against wild-type HIV-1 and mutant viruses (EC50 values are 0.4 and 0.1-2.0 nM, respectively in a cell-based assay). This compound is orally bioavailable.

技术数据 for Rilpivirine

分子量 366.42
公式 C22H18N6
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 500287-72-9
PubChem ID 6451164
InChI Key YIBOMRUWOWDFLG-ONEGZZNKSA-N
Smiles N(C1=C(C)C=C(/C=C/C#N)C=C1C)C2=NC(NC3=CC=C(C#N)C=C3)=NC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Rilpivirine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 18.32 50

制备储备液 for Rilpivirine

以下数据基于产品分子量 366.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.46 mL 27.29 mL 54.58 mL
2.5 mM 1.09 mL 5.46 mL 10.92 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
25 mM 0.11 mL 0.55 mL 1.09 mL

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参考文献 for Rilpivirine

参考文献是支持产品生物活性的出版物。

Janssen et al (2005) In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (R278474, rilpivirine) J.Med.Chem. 48 1901 PMID: 15771434

Baert et al (2009) Development of a long-acting injectable formulation with nanoparticles of rilpivirine (TMC278) for HIV treatment. Eur.J.Pharm.Biopharm. 72 502 PMID: 19328850

If you know of a relevant reference for Rilpivirine, please let us know.

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关键词: Rilpivirine, Rilpivirine supplier, reverse, transcriptase, inhibitors, inhibits, diarylpyrimidine, (DAPY), potent, antivirals, HIV-1, HIV, orally, bioavailable, NNRTI, non-nucleoside, DNA, Polymerase, 7684, Tocris Bioscience

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Epigenetics Scientific Review

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Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.