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说明： Potent BMP4 agonist
化学名： 2-[[(4-Bromophenyl)methyl]thio]benzoxazole
纯度： ≥99% (HPLC)
生物活性 for SB 4
SB 4 is a potent BMP4 agonist (EC50 = 74 nM). Activates canonical BMP signaling and increases SMAD-1/5/9 phosphorylation, with no effect on p-SMAD-2, p-SMAD-3 or p-TAK1. Bypasses noggin-induced inhibition of type I BMP receptors. When used in combination, SB 4 enhances BMP4 signaling and embryonic stem cell differentiation.
化合物库 for SB 4
SB 4 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for SB 4
| 分子量 | 320.2 |
| 公式 | C14H10BrNOS |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 100874-08-6 |
| PubChem ID | 731364 |
| InChI Key | JDVOIBFEFVKUPL-UHFFFAOYSA-N |
| Smiles | BrC1=CC=C(C=C1)CSC2=NC3=C(C=CC=C3)O2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SB 4
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 32.02 | 100 | |
| ethanol | 6.4 | 20 |
制备储备液 for SB 4
以下数据基于产品分子量 320.2。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.12 mL | 15.62 mL | 31.23 mL |
| 5 mM | 0.62 mL | 3.12 mL | 6.25 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.12 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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产品说明书 for SB 4
参考文献 for SB 4
参考文献是支持产品生物活性的出版物。
Bradford et al (2019) High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds. J.Biol.Chem. 294 3125 PMID: 30602563
Hayaei Tehrani et al (2022) A comparison between BMP4 and SB4 in inducing germ line gene expression pattern during embryonic stem cells differentiation. Differentiation 123 9 PMID: 34864442
If you know of a relevant reference for SB 4, please let us know.
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关键词: SB 4, SB 4 supplier, SB4, Potent, BMP4, agonists, agonism, SMAD, phosphorylation, canonical, BMP, signaling, activators, stem, cell, differentiation, and, Other, Activin, Receptors, ESCs, iPSC, 6881, Tocris Bioscience
1 篇 SB 4 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SB 4 的部分引用包括：
Hayaei Tehrani et al (2022) A comparison between BMP4 and SB4 in inducing germ line gene expression pattern during embryonic stem cells differentiation. Differentiation 123 9 PMID: 34864442
您是否知道使用了 Tocris SB 4 的优秀论文？ 请告知我们.
SB 4 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Pathways for SB 4
