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BMP and Other Activin Receptors

Activin receptors transduce signals carried by the TGF-β family of ligands. Such ligands include activin and bone morphogenetic proteins (BMPs). Members of this family are involved in a range of processes, including embryogenesis and tissue homeostasis.

Products
Background
文献 (4)
通路 (1)
Gene Data

BMP and Other Activin Receptor Agonists
Cat. No. 产品名称/活性
6881 SB 4
Potent BMP4 agonist

BMP and Other Activin Receptor Inhibitors
Cat. No. 产品名称/活性
6712 A 77-01
Potent inhibitor of TGF-βRI
2939 A 83-01
Selective inhibitor of TGF-βRI, ALK4 and ALK7
4126 DMH-1
Selective ALK2 inhibitor
5580 DMH2
Type I BMP receptor inhibitor
3093 Dorsomorphin dihydrochloride
BMP type I receptor (ALK2, ALK3 and ALK6) inhibitor
4986 K 02288
Type 1 BMP receptor inhibitor
6053 LDN 193189 dihydrochloride
Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs
7754 M4K2163 dihydrochloride
Potent and selective ALK2 inhibitor
4945 ML 347
Potent and selective ALK1 and ALK2 inhibitor
3263 SB 505124
Selective inhibitor of TGF-βRI, ALK4 and ALK7

Other
Cat. No. 产品名称/活性
5397 A01
Enhances BMP signaling; Smurf1 inhibitor
8150 LDN 193189 in solution
Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water
2694 PD 407824
Senzitizes cells to BMP4; potent and selective inhibitor of Chk1 and Wee1

Related Targets

    Activin receptors transduce signals carried by the TGF-β family of ligands. Such ligands include activin and bone morphogenetic proteins (BMPs). Members of this family are involved in a range of processes, including embryogenesis and tissue homeostasis.

    Bone morphogenetic proteins (BMPs) are a group of growth factors belonging to the transforming growth factor-β (TGF-β) superfamily (excluding BMP1). Primarily characterized by their effects on bone and cartilage formation, research has further elucidated a role for BMPs in cell growth and development.

    There are currently 20 known BMP isoforms, which form dimers in order to bind a tetrameric receptor complex composed of type I and type II BMP receptor subunits. ALK2, ALK3 and ALK6 function as BMP type I receptors, the latter of which are structurally similar. Three BMP type II receptors have also been identified: BMPR2, and type II and IIB activin receptors (ACVR2A and ACVR2B). ALK2, ACVR2A and ACVR2B also function as receptors for activins.

    Signal transduction is continued through Smad proteins. Receptor-regulated Smads (R-Smads) are phosphorylated by activation of type I receptors and form heteromeric complexes with Co-Smads. These complexes regulate the transcription of target genes in the nucleus.

    External sources of pharmacological information for BMP and Other Activin Receptors :

      Literature for BMP and Other Activin Receptors

      Tocris offers the following scientific literature for BMP and Other Activin Receptors to showcase our products. We invite you to request* your copy today!

      *Please note that Tocris will only send literature to established scientific business / institute addresses.

      Stem Cell Research Product Guide

      Stem Cell Research Product Guide

      This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

      • Self-renewal and Maintenance
      • Differentiation
      • Reprogramming
      • Organoid Generation
      • GMP and Ancillary Material Grade Products
      Stem Cells Scientific Review

      Stem Cells Scientific Review

      Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

      Stem Cell Workflow Poster

      Stem Cell Workflow Poster

      Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.

      Stem Cells Poster

      Stem Cells Poster

      Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

      Pathways for BMP and Other Activin Receptors

      TGF-β Signaling Pathway

      TGF-β Signaling Pathway

      The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.

      TGF-β Receptor Gene Data

      Gene Species Gene Symbol Gene Accession No. Protein Accession No.
      ACVR1
      (ALK2)       		Human ACVR1 NM_001105 -
      Rat Acvr1 NM_024486 P80201
      BMPR1A
      (ALK3)       		Human BMPR1A NM_004329 BC028383
      Mouse Bmpr1a NM_009758 P36895
      Rat Bmpr1a NM_0303849 Q78EA7
      ACVR1B
      (ALK4)       		Human ACVR1B NM_020328 -
      Mouse Acvr1b NM_007395 Q61271
      Rat Acvr1b NM_199230 EDL86909
      BMPR1B
      (ALK6)       		Human BMPR1B NM_001203 D89675
      Mouse Bmpr1b NM_007560 P36898
      Rat Bmpr1b NM_001024259 Q569A5
      BMPR2 Human BMPR2 - Z48923
      Mouse Bmpr2 NM_007561 O35607
      Rat Bmpr2 NM_080407 BAB71720
      ACVR2A Human ACVR2A NM_001616 -
      Mouse Acvr2a NM_007396 A2AI38
      Rat Acvr2a NM_113759.1 EDM00469
      ACVR2B Human ACVR2B NM_001106 X77533
      Mouse Acvr2b NM_007397 -
      Rat Acvr2b NM_031554 NP_113742