Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewML 347
Description: Potent and selective ALK1 and ALK2 inhibitor
Alternative Names: LDN 193719,1lWY,VU0469381
Chemical Name: 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Purity: ≥98% (HPLC)
Biological Activity for ML 347
ML 347 is a potent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits BMP4 signaling in a functional assay (IC50 = 152 nM).
Compound Libraries for ML 347
ML 347 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
Technical Data for ML 347
| M. Wt | 352.39 |
| Formula | C22H16N4O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1062368-49-3 |
| PubChem ID | 44577753 |
| InChI Key | FVRYPYDPKSZGNS-UHFFFAOYSA-N |
| Smiles | COC(C=C3)=CC=C3C(C=N2)=CN1C2=C(C4=CC=CC5=C4C=CC=N5)C=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 347
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.05 | 20 |
Preparing Stock Solutions for ML 347
The following data is based on the product molecular weight 352.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 14.19 mL | 70.94 mL | 141.89 mL |
| 1 mM | 2.84 mL | 14.19 mL | 28.38 mL |
| 2 mM | 1.42 mL | 7.09 mL | 14.19 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.84 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for ML 347
References for ML 347
References are publications that support the biological activity of the product.
Engers et al (2013) Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN Bioorg Med Chem Lett. 23 3248 PMID: 23639540
If you know of a relevant reference for ML 347, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ML 347, ML 347 supplier, ML347, Potent, selective, ALK1, ALK2, BMP, activin, receptor, like, kinase, Bone, morphogenetic, proteins, inhibitors, inhibits, LDN, 193719, 1LWY, VU0469381, and, Other, Activin, Receptors, 4945, Tocris Bioscience
2 Citations for ML 347
Citations are publications that use Tocris products. Selected citations for ML 347 include:
Varadaraj et al (2015) Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia. Neoplasia 17 826 PMID: 26678910
Kathleen et al (2022) Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer. Cell Rep 40 111066 PMID: 35905726
Do you know of a great paper that uses ML 347 from Tocris? Please let us know.
Reviews for ML 347
There are currently no reviews for this product. Be the first to review ML 347 and earn rewards!
Have you used ML 347?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Pathways for ML 347
