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TAT-Gap19

Cat. No. 6227 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Cx43 hemichannel blocker
纯度： ≥95% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TAT-Gap19

TAT-Gap19 is a Cx43 hemichannel blocker (IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19 (Cat. No. 5353). Active in vivo. Brain penetrant.

技术数据 for TAT-Gap19

分子量 2703.28
公式 C119H212N46O26
序列 YGRKKRRQRRRKQIEIKKFK
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 1507930-54-2
PubChem ID 127021051
InChI Key ALNCFPIRTLVJPY-XELKYWHDNA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TAT-Gap19

溶解性 Soluble to 1 mg/ml in water

产品说明书 for TAT-Gap19

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for TAT-Gap19

参考文献是支持产品生物活性的出版物。

Abudara et al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front.Cell.Neurosci. 8 1 PMID: 25374505

Freitas-Andrade and Naus (2016) Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1. Neuroscience. 323 207 PMID: 25913636

If you know of a relevant reference for TAT-Gap19, please let us know.

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关键词: TAT-Gap19, TAT-Gap19 supplier, Inhibitors, Inhibits, connexin43, Cx43, Brain, penetrant, Cell, permeable, Gap, Channels, 6227, Tocris Bioscience

2 篇 TAT-Gap19 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TAT-Gap19 的部分引用包括：

Wei et al (2020) Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling. J Neuroinflammation 17 322 PMID: 33115476

Matthias M et al (2020) Connexin 43 gap junctional intercellular communication inhibits evx1 expression and joint formation in regenerating fins. Development 147 PMID: 32541014

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