mTOR Signaling Pathway
ERK1/2 Insulin
Receptor Growth
Factor
Receptor p53 PKCα PDK1 Akt p90 RSK p70 S6K Wnt AMPK GSK-3 PPARγ PP2A Autophagy Rapamycin Angiogenesis mTOR mTOR PI3K
Receptor Growth
Factor
Receptor p53 PKCα PDK1 Akt p90 RSK p70 S6K Wnt AMPK GSK-3 PPARγ PP2A Autophagy Rapamycin Angiogenesis mTOR mTOR PI3K
mTOR (mammalian target of Rapamycin) integrates signals both intercellularly and extracellularly to regulate growth, proliferation, metabolism and survival. It can form two complexes within the cell, known as mTORC1 and mTORC2 which are dependent on their regulatory proteins Raptor and Rictor respectively. mTOR is important for both the Akt and insulin signal transduction pathways and is deregulated in cancer and Type 2 diabetes.
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Signaling Pathway Key
Stimulates
Inhibits
Multistep Inhibition
Multistep Activation
Multistep Upregulation
Kinase
Transcription Factor
Enzyme-linked Receptor
Other Enzyme
Other Protein
7-TM Receptor
Phosphatase
