Adenosine A2A Receptors
Adenosine A2A receptors are members of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2B and A3. A2A receptors display high expression levels in the spleen, thymus, leukocytes, blood platelets and the olfactory bulb.
Adenosine A2A Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 1063 | CGS 21680 hydrochloride |
| A2A agonist | |
| 4603 | LUF 5834 |
| Potent adenosine A2A and A2B receptor partial agonist | |
| 4334 | PSB 0777 ammonium salt |
| Potent adenosine A2A agonist | |
Adenosine A2A Receptor Inverse Agonists |
|
| Cat. No. | Product Name / Activity |
| 5901 | c-Di-AMP sodium salt |
| A2A inverse agonist; also endogenous STING and DDX41 agonist | |
Adenosine A2A Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 3937 | ANR 94 |
| Adenosine A2A antagonist | |
| 5147 | Istradefylline |
| Potent and selective A2A antagonist | |
| 2463 | SCH 442416 |
| Very selective, high affinity A2A antagonist | |
| 2270 | SCH 58261 |
| Potent, highly selective A2A antagonist | |
| 4407 | TC-G 1004 |
| Potent and selective A2A antagonist | |
| 1036 | ZM 241385 |
| Potent and highly selective A2A antagonist | |
Adenosine A2A receptors are members of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2B and A3. A2A receptors display high expression levels in the spleen, thymus, leukocytes, blood platelets, striatopallidal GABAergic neurons and the olfactory bulb. Lower expression levels are also found in the heart, lungs and blood vessels. A2A receptors mediate a sustained cardioprotective function during cardiac ischemia, inhibit neutrophil degranulation in neutrophil-mediated tissue injury and have been implicated in both neuroprotective and neurodegenerative effects. The human A2A receptor gene is localized on chromosome 22 (22q11.23).
Both A2A and A2B receptors are important in cancer immunology. The tumor microenvironment is hypoxic, which promotes the expression of CD39 and CD73 by immune cells. CD39 and CD73 are ectonucleotidases that convert ATP to adenosine, elevating concentrations of adenosine locally. Adenosine is a crucial mediator of altered immune function in cancer as it binds A2A and A2B receptors on lymphocytes silencing the antitumor immune response.
External sources of pharmacological information for Adenosine A2A Receptors :
Literature for Adenosine A2A Receptors
Tocris offers the following scientific literature for Adenosine A2A Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Written by Anthony H.V. Schapira
Our Parkinson's disease (PD) poster summarizes the neurobiology of the disease, and highlights current therapeutic treatments for symptomatic PD.
Request copyDownload PDF