ASK1
Apoptosis signal-regulated kinase 1 (ASK1) is a serine/threonine kinase, MAP3K family member, which induces apoptosis through the activation of JNK and p38. ASK1 has been implicated in the pathology of neurodegenerative and oxidative stress-related diseases.
ASK1 Inhibitors |
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|---|---|
| Cat. No. | Product Name / Activity |
| 5641 | MSC 2032964A |
| Potent and selective ASK1 inhibitor; orally bioavailable | |
| 4825 | TC ASK 10 |
| Potent and selective ASK1 inhibitor; orally bioavailable | |
Apoptosis signal-regulated kinase 1 (ASK1) is a ubiquitously expressed serine/threonine kinase which induces apoptosis in a wide variety of cell types. ASK1 is a member of the MAP3K family and is therefore part of the MAPK signaling pathway. The kinase activates JNK and p38 through phosphorylation of SEK1/MKK7 and MKK3/MKK6 respectively, which induces mitochondria-dependent caspase activation and subsequent apoptosis. ASK1 is activated following auto-phosphorylation of Thr845 (mouse)/Thr838 (human) in the activation loop of its kinase domain, whilst Raf1 and the 14.3.3 proteins interact with ASK1 to suppress its proapoptotic activity.
ASK1-induced apoptosis can be activated by a number of stimuli, including: reactive oxygen species (ROS) such as hydrogen peroxide; death receptor ligands e.g. TNF-α and Fas ligand; endoplasmic reticulum (ER) stress; and lipopolysaccharide, GPCR and Ca2+ signaling. ASK1 has been implicated in the pathology of oxidative stress-related disease states such as ischemia-reperfusion injury and hematopoietic diseases, as well as in the role of ER stress in the pathogenesis of neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's disease.
External sources of pharmacological information for ASK1 :
Literature for ASK1
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