Estrogen (GPER) Receptors
The GPER (G protein-coupled estrogen receptor, GPR30) is a membrane protein that binds estrogen leading to estrogen-mediated adenylyl cyclase stimulation. The receptor is widely distributed in neural, breast, placental, heart, ovarian, prostate and hepatic tissues.
Estrogen (GPER) Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 7811 | CITFA |
| Potent G protein-coupled estrogen receptor (GPER) agonist | |
| 2824 | β-Estradiol |
| Endogenous ER agonist | |
| 3577 | G-1 |
| Potent and selective GPER agonist | |
| 1110 | Genistein |
| GPER agonist. Also tyrosine kinase inhibitor | |
| 1047 | ICI 182,780 |
| High affinity GPER agonist | |
| 1125 | Quercetin |
| GPER agonist. Also non-selective PI 3-kinase inhibitor | |
| 0999 | Tamoxifen citrate |
| High affinity GPER agonist | |
Estrogen (GPER) Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 6116 | BHPI |
| ERα antagonist; also activates unfolded protein response; active in vivo | |
| 7812 | CIMBA hydrochloride |
| Potent and selective G protein-coupled estrogen receptor (GPER) antagonist | |
| 3678 | G-15 |
| High affinity and selective GPER antagonist | |
| 4759 | G-36 |
| Selective GPER antagonist | |
The GPER (G protein-coupled estrogen receptor, GPR30) is a membrane protein that binds estrogen leading to estrogen-mediated adenylyl cyclase stimulation. The receptor is widely distributed in neural, breast, placental, heart, ovarian, prostate, hepatic, vascular epithelial and lymphoid tissues. The GPER binds estradiol with high affinity, but has lower affinity for the other estrogens, estrone and estriol. The receptor acts independently of ERα and ERβ and triggers ER-dependent EGFR action.
External sources of pharmacological information for Estrogen (GPER) Receptors :
Pathways for Estrogen (GPER) Receptors
