Melanin-concentrating Hormone Receptors
Melanin-concentrating hormone (MCH) is a neuropeptide that is expressed in the central and peripheral nervous systems and plays an important role in the control of feeding behaviors and energy metabolism. MCH acts on two GPCRs: MCH1 (GPR24) and MCH2 (GPR145).
Melanin-concentrating Hormone Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 3806 | MCH (human, mouse, rat) |
| Potent endogenous MCH agonist | |
Melanin-concentrating Hormone Receptor Antagonists |
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| Cat. No. | Product Name / Activity |
| 4242 | GW 803430 |
| MCH1 antagonist | |
| 3347 | SNAP 94847 hydrochloride |
| Potent and selective MCH1 antagonist | |
| 4365 | TC-MCH 7c |
| Selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist | |
Melanin-concentrating hormone (MCH) is a neuropeptide that is expressed in the central and peripheral nervous systems and plays an important role in the control of feeding behaviors and energy metabolism. MCH acts on two GPCRs: MCH1 (GPR24) and MCH2 (GPR145).
MCH1 and MCH2 have very similar tissue distribution patterns and are expressed in many brain regions, particularly the ventromedial, dorsalmedial and arcuate nuclei of the hypothalamus and zona incerta. They are also found at lower levels in the periphery including in the pituitary gland, adipose tissue and pancreas. MCH1 is a target for the orexigenic peptide leptin, which supports a role for MCH receptors in the control of food intake and energy expenditure. The human genes encoding MCH1 and MCH2 are localized to chromosomes 22q13.3 and 6q21 respectively. MCH2 is a pseudogene in rodents.
External sources of pharmacological information for Melanin-concentrating Hormone Receptors :
Literature for Melanin-concentrating Hormone Receptors
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis.
Request copyRequest PDFWritten by P. Skolnich et al
Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder.
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