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Protein Kinase G

Protein Kinase G (PKG) is a cyclic GMP-dependent protein serine/threonine kinase that phosphorylates a variety of biological targets. There are two subtypes of PKG: PKG1 and PKG2 and, due to alternative exon splicing, two isoforms of PKG1 - PKG1α and PKG1β.

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Background
Literature (1)
Gene Data

Protein Kinase G Inhibitors
Cat. No. Product Name / Activity
6626 AP C5
Potent and selective PKG2 inhibitor
3028 Rp-8-Br-PET-cGMPS
Protein kinase G inhibitor
1289 KT 5823
Selective protein kinase G inhibitor

Protein Kinase G Activators
Cat. No. Product Name / Activity
1089 8-Bromo-cGMP, sodium salt
cGMP analog; activates protein kinase G

Related Targets

    Protein kinase G (PKG) is a cyclic GMP-dependent protein serine/threonine kinase that phosphorylates a variety of biological targets. There are two subtypes of PKG: PKG1 and PKG2. Due to alternative exon splicing two isoforms of PKG1, PKG1α and PKG1β, exist.

    PKG1 and PKG2 are expressed in different cell types, with PKG1 at its highest concentrations in smooth muscle cells and platelets, whilst PKG2 is most abundant in the brain, lungs and intestinal mucosa. PKGs exist as antiparallel homodimers and have roles in smooth muscle relaxation (via phosphorylation of myosin light chain phosphatase), platelet function, spermatozoa metabolism and hemodynamic homeostasis. In addition, it has been suggested that PKG has anticancer properties due to its role in upregulating expression of the tumor suppressor genes p21, p27 and histidine triad protein 1 (HINT1).

    External sources of pharmacological information for Protein Kinase G :

    Literature for Protein Kinase G

    Tocris offers the following scientific literature for Protein Kinase G to showcase our products. We invite you to request* your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.

    Angiogenesis in Cancer Poster

    Angiogenesis in Cancer Poster

    This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

    Protein Kinase G Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    PKG1 Human PRKG1 NM_006258 Q13976
    Mouse Prkg1 NM_001013833 Q9Z0Z0
    Rat Prkg1 NM_001105731 XP_219805
    PKG2 Human PRKG2 NM_006259 Q13237
    Mouse Prkg2 NM_008926 Q61410
    Rat Prkg2 NM_013012 Q64595