Syk Kinase
Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based activation motifs (ITAMs) to activate the enzyme.
Syk Kinase Inhibitors |
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|---|---|
| Cat. No. | Product Name / Activity |
| 2471 | ER 27319 maleate |
| Selective Syk kinase inhibitor | |
| 6362 | GSK 143 |
| Syk inhibitor | |
| 5592 | LCB 03-0110 dihydrochloride |
| Potent Syk kinase inhibitor; also inhibits BTK, c-Src and DDR2 | |
| 1554 | Piceatannol |
| Syk and p56lck kinase inhibitor | |
Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based activation motifs (ITAMs) to activate and autophosphorylate the enzyme. This allows Syk to phosphorylate its specific substrates including other enzymes and adaptor proteins, orchestrating a complex series of cellular responses such as cell proliferation, differentiation, survival and phagocytosis.