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Submit Review4F 4PP oxalate is a selective 5-HT2A antagonist with almost as high affinity (Ki = 5.3 nM) as Ketanserin (Cat. No. 0908) but with a much lower affinity for 5-HT2C sites (Ki = 620 nM).
M. Wt | 429.49 |
Formula | C22H26FNO.C2H2O4 |
Storage | Store at RT |
Purity | ≥99% (HPLC) |
CAS Number | 144734-36-1 |
PubChem ID | 24745966 |
InChI Key | VUJYJCRJPFMHEM-UHFFFAOYSA-N |
Smiles | OC(=O)C(O)=O.FC1=CC=C(C=C1)C(=O)C1CCN(CCCCC2=CC=CC=C2)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 100 | ||
ethanol | 20 |
The following data is based on the product molecular weight 429.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.33 mL | 11.64 mL | 23.28 mL |
5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
10 mM | 0.23 mL | 1.16 mL | 2.33 mL |
50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
References are publications that support the biological activity of the product.
Hagberg et al (1998) Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels. Neurochem.Int. 32 153 PMID: 9542727
Herndon et al (1992) Ketanserin analogues - structure affinity relationships of 5HT2 and 5HT1C serotonin receptor binding. J.Med.Chem. 35 4903 PMID: 1479590
If you know of a relevant reference for 4F 4PP oxalate, please let us know.
Keywords: 4F 4PP oxalate, 4F 4PP oxalate supplier, Selective, 5-HT2A, antagonists, Serotonin, Receptors, 5-HT2, 4F4PP, oxalate, 0523, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for 4F 4PP oxalate include:
Lee et al (2018) Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice. J Allergy Clin Immunol 142 1349 PMID: 29920354
Rodríguez-Muñoz et al (2018) Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors. Oncotarget 9 23373 PMID: 29805740
Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641
Do you know of a great paper that uses 4F 4PP oxalate from Tocris? Please let us know.
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