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AC 261066

Cat. No. 4046 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: RARβ2 agonist
Chemical Name: 4-[4-(2-Butoxyethoxy-)-5-methyl-2-thiazolyl]-2-fluorobenzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AC 261066

AC 261066 is a potent RARβ2 agonist (pEC50 = 8.1). Selective over RARβ1, RARα and RARγ (pEC50 values are 6.4, 6.2 and 6.3 respectively). More potent and orally available than AC 55649 (Cat. No. 2436).

Compound Libraries for AC 261066

AC 261066 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AC 261066

M. Wt 353.41
Formula C17H20FNO4S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 870773-76-5
PubChem ID 11530459
InChI Key HSAOETBFVAWNRP-UHFFFAOYSA-N
Smiles CC1=C(OCCOCCCC)N=C(C2=CC=C(C(O)=O)C(F)=C2)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AC 261066

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.34 100
ethanol 35.34 100

Preparing Stock Solutions for AC 261066

The following data is based on the product molecular weight 353.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.15 mL 28.3 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.41 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

Molarity Calculator

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Dilution Calculator

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References for AC 261066

References are publications that support the biological activity of the product.

Lund et al (2005) Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist. J.Med.Chem. 48 7517 PMID: 16302793

Lund et al (2009) Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor β ligands. J.Med.Chem. 52 1540 PMID: 19239230

If you know of a relevant reference for AC 261066, please let us know.

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Keywords: AC 261066, AC 261066 supplier, AC261066, RAR, retinoic, acid, receptor, agonists, beta, b, β, agonist, Retinoic, Acid, Receptors, 4046, Tocris Bioscience

1 Citation for AC 261066

Citations are publications that use Tocris products. Selected citations for AC 261066 include:

Lorraine J et al (2022) A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes. Biofactors 48 469-480 PMID: 34687254

Do you know of a great paper that uses AC 261066 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.