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Submit ReviewAM 80
Description: RARα agonist; anticancer agent
Alternative Names: Tamibarotene
Chemical Name: 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid
Purity: ≥98% (HPLC)
Biological Activity for AM 80
AM 80 is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo. AM 80 is a cell cycle activator in hiPSC-derived cardiomyocytes, and pretreatment with AM 80 promotes engraftment of cardiomyocytes in mice with heart damage.
Compound Libraries for AM 80
AM 80 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for AM 80
| M. Wt | 351.44 |
| Formula | C22H25NO3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 94497-51-5 |
| PubChem ID | 108143 |
| InChI Key | MUTNCGKQJGXKEM-UHFFFAOYSA-N |
| Smiles | O=C(C3=CC=C(C(O)=O)C=C3)NC(C=C2)=CC1=C2C(C)(C)CCC(C)1C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AM 80
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.57 | 50 | |
| ethanol | 17.57 | 50 |
Preparing Stock Solutions for AM 80
The following data is based on the product molecular weight 351.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.69 mL | 28.45 mL | 56.91 mL |
| 2.5 mM | 1.14 mL | 5.69 mL | 11.38 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.69 mL |
| 25 mM | 0.11 mL | 0.57 mL | 1.14 mL |
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Product Datasheets for AM 80
References for AM 80
References are publications that support the biological activity of the product.
Kagechika et al (1988) Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity. J.Med.Chem. 31 2182 PMID: 3184125
Jimi et al (2007) RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. Int.J.Oncol. 31 397 PMID: 17611697
Takenaga et al (2009) The effects of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats. Biol.Pharm.Bull. 32 225 PMID: 19182380
Kasamoto et al (2023) Am80, a retinoic acid receptor agonist, activates the cardiomyocyte cell cycle and enhances engraftment in the heart. Stem Cell Reports S2213-6711 00235-7 PMID: 37451261
If you know of a relevant reference for AM 80, please let us know.
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Keywords: AM 80, AM 80 supplier, RARα, RARalpha, agonists, anticancer, Retinoic, Acid, Receptors, AM80, cardiomyocytes, cell, cycle, activators, activation, Tamibarotene, Cardiomyocyte, Stem, Cells, 3507, Tocris Bioscience
2 Citations for AM 80
Citations are publications that use Tocris products. Selected citations for AM 80 include:
Duprey-Díaz et al (2016) Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System afterOptic Nerve Injury PLoS One 11 e0162626 PMID: 27611191
Mickaël M et al (2020) A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV. Cell Rep 30 914-931.e9 PMID: 31968263
Do you know of a great paper that uses AM 80 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.