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AMG 18 hydrochloride

Cat. No. 6166 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective IRE1α inhibitor
Chemical Name: 2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AMG 18 hydrochloride

AMG 18 hydrochloride is a potent and selective IRE1α inhibitor (IC50 values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases.

Technical Data for AMG 18 hydrochloride

M. Wt 637.58
Formula C31H29ClN6O3S.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2250019-92-0
PubChem ID 134160238
InChI Key CNWIPRHGMZTPSB-BOXHHOBZSA-N
Smiles CC1=C(C2=C(C(NS(=O)(C3=C(C=CC=C3)Cl)=O)=CC=C2)C=C1)OC4=C(C5=NC(N[C@H]6CCCNC6)=NC=C5)C=CC=N4.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AMG 18 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 63.76 100
DMSO 63.76 100

Preparing Stock Solutions for AMG 18 hydrochloride

The following data is based on the product molecular weight 637.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.57 mL 7.84 mL 15.68 mL
5 mM 0.31 mL 1.57 mL 3.14 mL
10 mM 0.16 mL 0.78 mL 1.57 mL
50 mM 0.03 mL 0.16 mL 0.31 mL

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Product Datasheets for AMG 18 hydrochloride

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for AMG 18 hydrochloride

References are publications that support the biological activity of the product.

Harrington et al (2014) Unfolded protein response in cancer: IRE1α inhibition by selective kinase ligands does not impair tumor cell viability. ACS Med.Chem.Lett. 6 68 PMID: 25589933

If you know of a relevant reference for AMG 18 hydrochloride, please let us know.

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2 Citations for AMG 18 hydrochloride

Citations are publications that use Tocris products. Selected citations for AMG 18 hydrochloride include:

Michael C et al (2022) Targeting IRE1 endoribonuclease activity alleviates cardiovascular lesions in a murine model of Kawasaki disease vasculitis. JCI Insight 7 PMID: 35167493

Xu et al (2019) The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine-induced ER stress response. JCI Insight 4 PMID: 30843874

Do you know of a great paper that uses AMG 18 hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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