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Description: Inhibits replication of SARS-CoV-2 in vitro; broad spectrum antiviral
Chemical Name: Ethyl 6-Bromo-4-((dimethylamino)methyl)-5-hydroxy-1-methyl-2-((phenylthio)methyl)-1H-indole-3-carboxylate hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Arbidol
Arbidol is a broad spectrum antiviral. Displays activity against a range of respiratory and hepatitis viruses including influenza A, B and C, adenovirus, and hepatitis B and C. Increases stability of influenza viral hemagglutinins (HA) and prevents low-pH HA transition so inhibiting viral fusion. Also inhibits SARS-CoV-2 infection in vitro (IC50 = 4.11 μM).
Compound Libraries for Arbidol
Arbidol is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for Arbidol
| M. Wt | 513.88 |
| Formula | C22H25BrN2O3S.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 131707-23-8 |
| PubChem ID | 9958103 |
| InChI Key | OMZHXQXQJGCSKN-UHFFFAOYSA-N |
| Smiles | Cl.CCOC(=O)C1=C(CSC2=CC=CC=C2)N(C)C2=CC(Br)=C(O)C(CN(C)C)=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Arbidol
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 51.39 | 100 | |
| DMSO | 51.39 | 100 |
Preparing Stock Solutions for Arbidol
The following data is based on the product molecular weight 513.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.95 mL | 9.73 mL | 19.46 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.89 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.95 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
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Product Datasheets for Arbidol
References for Arbidol
References are publications that support the biological activity of the product.
Boriskin et al (2008) Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr.Med.Chem. 15 997 PMID: 18393857
Wang et al (2020) The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 6 28 PMID: 32373347
If you know of a relevant reference for Arbidol, please let us know.
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Citations for Arbidol
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