Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewBAM 22P
Discontinued Product
1650 has been discontinued.
View all Mas-Related G Protein-Coupled Receptors products.
Description: MRGPRX1 agonist; also opioid receptor agonist
Alternative Names: Bovine adrenal medullary peptide-22P,BAM 22 (1-22)
Biological Activity for BAM 22P
Potent endogenous agonist peptide for Mas-related G proteins-coupled receptor X1 (MRGPRX1); isolated from bovine adrenal medulla (EC50 values are 16 - 800 nM) Also potent opioid agonist (IC50 = 1.3 nM in guinea pig ileum preparation). Produces opioid- and non-opioid receptor mediated antinociceptive effects in vivo.
Technical Data for BAM 22P
| M. Wt | 2839.24 |
| Formula | C130H184N38O31S2 |
| Sequence | YGGFMRRVGRPEWWMDYQKRYG |
| Storage | Desiccate at -20°C |
| CAS Number | 76622-26-9 |
| PubChem ID | 16132339 |
| InChI Key | QYDAFJUKVGVEKO-PKOVDKIBSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BAM 22P
References for BAM 22P
References are publications that support the biological activity of the product.
Hong et al (2004) Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain - potential function of a novel receptor. Br.J.Pharmacol. 141 423 PMID: 14718254
Lembo et al (2002) Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nat.Neurosci. 5 201 PMID: 11850634
Mizuno et al (1980) A new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity. Biochem.Biophys.Res.Commun. 97 1283 PMID: 7213356
Simonin and Kieffer (2002) Two faces for an opioid peptide - and more receptors for pain research. Nat.Neurosci. 5 185 PMID: 11865303
Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 66 570 PMID: 24867890
View Related Products by Target
View Related Products by Product Action
Keywords: BAM 22P, BAM 22P supplier, agonists, sensory, neuron-specific, receptors, SNSR, Opioids, BAM22P, BAM22(1-22), agonism, mas-related, g, protein-coupled, MRGPRX1, Bovine, adrenal, medullary, peptide-22P, BAM, 22, (1-22), Miscellaneous/Non-selective, Mas-related, G, Protein-Coupled, Receptors, 1650, Tocris Bioscience
1 Citation for BAM 22P
Citations are publications that use Tocris products. Selected citations for BAM 22P include:
Gupta et al (2014) Opioid receptor function is regulated by post-endocytic peptide processing. J Biol Chem 289 19613 PMID: 24847082
Reviews for BAM 22P
There are currently no reviews for this product. Be the first to review BAM 22P and earn rewards!
Have you used BAM 22P?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image