Home / Pharmacology / Enzymes / Dehydrogenases / Other Dehydrogenases / Other Dehydrogenase Inhibitors / BI 3231

BI 3231

Cat. No. 8039 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor
Chemical Name: 1-[[5-(2,4-Difluoro-3-hydroxyphenyl)-1,3,4-thiadiazol-2-yl]methyl]-3-ethyl-5-methyl-2,4(1H,3H)pyrimidinedione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BI 3231

BI 3231 is a potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor (IC50 values are 1 nM and 13 nM at hHSD17B13 and mHSD17B13 respectively; Ki = 0.7 nM). Reduces palmitic acid-induced toxicity in hepatocytes. Suitable for use in vivo and in vitro.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 3231 probe summary on the SGC website.

Technical Data for BI 3231

M. Wt 380.37
Formula C16H14F2N4O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2894848-07-6
PubChem ID 167312378
InChI Key XKDHFIPNTTUSIA-UHFFFAOYSA-N
Smiles O=C1C(C)=CN(CC2=NN=C(C3=C(F)C(O)=C(F)C=C3)S2)C(N1CC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BI 3231

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.8 10 with gentle warming

Preparing Stock Solutions for BI 3231

The following data is based on the product molecular weight 380.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.29 mL 131.45 mL 262.9 mL
0.5 mM 5.26 mL 26.29 mL 52.58 mL
1 mM 2.63 mL 13.15 mL 26.29 mL
5 mM 0.53 mL 2.63 mL 5.26 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for BI 3231

References are publications that support the biological activity of the product.

Thamm et al (2023) Discovery of a novel potent and selective HSD17B13 inhibitor, BI-3231, a well-characterized chemical probe available for open science. J.Med.Chem. 66 2832 PMID: 36727857

If you know of a relevant reference for BI 3231, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Dehydrogenase Inhibitors

Keywords: BI 3231, BI 3231 supplier, BI3231, hydroxysteroid, 17beta, 17b, dehydrogenase, 13, HSD17B13, inhibitor, inhibits, inhibitors, potent, selective, hepatocytes, NASH, non, alcoholic, steatohepatitis, Other, Dehydrogenases, 8039, Tocris Bioscience

Citations for BI 3231

Citations are publications that use Tocris products.

Currently there are no citations for BI 3231. Do you know of a great paper that uses BI 3231 from Tocris? Please let us know.

Reviews for BI 3231

There are currently no reviews for this product. Be the first to review BI 3231 and earn rewards!

Have you used BI 3231?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.