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Submit ReviewBI 6015
Description: Hepatocyte nuclear factor 4α (HNF4α) antagonist
Chemical Name: 2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole
Purity: ≥98% (HPLC)
Biological Activity for BI 6015
BI 6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist. Represses expression of known HNF4α target genes. Decreases HNF4α DNA binding. Exhibits cytotoxic activity in a range of tumor cell lines, including human hepatocellular carcinoma.
Compound Libraries for BI 6015
BI 6015 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for BI 6015
| M. Wt | 331.35 |
| Formula | C15H13N3O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 93987-29-2 |
| PubChem ID | 3269393 |
| InChI Key | ILVCPQPMRPHZSG-UHFFFAOYSA-N |
| Smiles | CC2=NC1=CC=CC=C1N2S(C3=C(C)C=CC([N+]([O-])=O)=C3)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BI 6015
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.63 | 20 |
Preparing Stock Solutions for BI 6015
The following data is based on the product molecular weight 331.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 15.09 mL | 75.45 mL | 150.9 mL |
| 1 mM | 3.02 mL | 15.09 mL | 30.18 mL |
| 2 mM | 1.51 mL | 7.54 mL | 15.09 mL |
| 10 mM | 0.3 mL | 1.51 mL | 3.02 mL |
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Product Datasheets for BI 6015
References for BI 6015
References are publications that support the biological activity of the product.
Kiselyuk et al (2012) HNF4α antagonists discovered by a high-throughput screen for modulators of the human Ins promoter. Chem.Biol. 19 806 PMID: 22840769
If you know of a relevant reference for BI 6015, please let us know.
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Keywords: BI 6015, BI 6015 supplier, BI6015, Hepatocyte, nuclear, factor, 4, alpha, HNF4a, HNF4α, antagonists, DNA, binding, cancer, Other, Transcription, Factors, 4641, Tocris Bioscience
3 Citations for BI 6015
Citations are publications that use Tocris products. Selected citations for BI 6015 include:
Levy et al (2016) Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection Nature Chemical Biology 12 1037 PMID: 27723751
David J et al (2023) Pharmacologic inhibition of HNF4α prevents parenteral nutrition associated cholestasis in mice. Sci Rep 13 7752 PMID: 37173326
Hu et al (2018) Berberine Attenuated Proliferation, Invasion and Migration by Targeting the AMPK/HNF4α/WNT5A Pathway in Gastric Carcinoma. Front Pharmacol 9 1150 PMID: 30405404
Do you know of a great paper that uses BI 6015 from Tocris? Please let us know.
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