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Submit ReviewCDK8/19i
Description: Potent and selective CDK8 and CDK19 inhibitor; maintains pluripotency of mouse PSCs in culture
Chemical Name: N-Propyl-3-(4-pyridinyl)imidazo[1,2-b]pyridazin-6-amine
Purity: ≥98% (HPLC)
Biological Activity for CDK8/19i
CDK8/19i is a potent and selective CDK8 and CDK19 inhibitor (IC50 values are 2.9 and 14.1 nM, respectively). CDK8/19i maintains pluripotency of mouse PSCs in culture. It induces the formation of dome-shaped colonies and upregulates Nanog-GFP reporter and endogenous Nanog expression in mouse ESCs in vitro.
Compound Libraries for CDK8/19i
CDK8/19i is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
Technical Data for CDK8/19i
| M. Wt | 253.3 |
| Formula | C14H15N5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 923596-52-5 |
| PubChem ID | 68488430 |
| InChI Key | XTMROGQLIVGYKF-UHFFFAOYSA-N |
| Smiles | CCCNC1=NN2C(C=C1)=NC=C2C3=CC=NC=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CDK8/19i
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.33 | 100 | |
| ethanol | 25.33 | 100 |
Preparing Stock Solutions for CDK8/19i
The following data is based on the product molecular weight 253.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.95 mL | 19.74 mL | 39.48 mL |
| 5 mM | 0.79 mL | 3.95 mL | 7.9 mL |
| 10 mM | 0.39 mL | 1.97 mL | 3.95 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.79 mL |
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Product Datasheets for CDK8/19i
References for CDK8/19i
References are publications that support the biological activity of the product.
Lynch et al (2020) Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases. Nat.Cell.Bio. 22 1223 PMID: 32989249
If you know of a relevant reference for CDK8/19i, please let us know.
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Keywords: CDK8/19i, CDK8/19i supplier, cyclin, dependent, kinases, inhibitors, inhibits, CDK8, CDK19, stem, cells, pluripotency, pluripotent, maintenance, self-renewal, potent, selective, Stem, Cell, Proliferation, Transcriptional, CDKs, 7372, Tocris Bioscience
Citations for CDK8/19i
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