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Description: TAF1 inhibitor
Chemical Name: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-2-methyl-1-oxo-4-isoquinolinecarboxamide
Purity: ≥98% (HPLC)
Biological Activity for CeMMEC1
CeMMEC1 is a TAF1 inhibitor (Kd = 1.8 μM, IC50 = 900 nM). CeMMEC1 impairs cell viability in combination with (+)-JQ1 (Cat. No. 4499) and inhibits proliferation of THP-1 and H23 lung adenocarcinoma cells.
Compound Libraries for CeMMEC1
CeMMEC1 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for CeMMEC1
| M. Wt | 336.35 |
| Formula | C19H16N2O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 440662-09-9 |
| PubChem ID | 24152379 |
| InChI Key | PEOQAZBGLOADFJ-UHFFFAOYSA-N |
| Smiles | CN1C=C(C(=O)NC2=CC=C3OCCOC3=C2)C2=CC=CC=C2C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CeMMEC1
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.63 | 100 |
Preparing Stock Solutions for CeMMEC1
The following data is based on the product molecular weight 336.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.97 mL | 14.87 mL | 29.73 mL |
| 5 mM | 0.59 mL | 2.97 mL | 5.95 mL |
| 10 mM | 0.3 mL | 1.49 mL | 2.97 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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Product Datasheets for CeMMEC1
References for CeMMEC1
References are publications that support the biological activity of the product.
Sdelci et al (2016) Mapping the chemical chromatin reactivation landscape identifies BRD 4-TAtaF1 cross-talk. Nat.Chem.Biol. 12 504 PMID: 27159579
If you know of a relevant reference for CeMMEC1, please let us know.
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Keywords: CeMMEC1, CeMMEC1 supplier, TAF1, bromodomain, inhibits, inhibitors, Bromodomains, 7139, Tocris Bioscience
Citations for CeMMEC1
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