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Submit ReviewCetirizine dihydrochloride
Discontinued Product
2577 has been discontinued.
View all Histamine H<sub>1</sub> Receptors products.
Description: Selective H1 antagonist
Alternative Names: P 071
Chemical Name: [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Cetirizine dihydrochloride
Cetirizine dihydrochloride is a histamine H1 receptor antagonist that displays selectivity over other receptors at concentrations up to 10 μM. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo.
Technical Data for Cetirizine dihydrochloride
| M. Wt | 461.81 |
| Formula | C21H25ClN2O3.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 83881-52-1 |
| PubChem ID | 55182 |
| InChI Key | PGLIUCLTXOYQMV-UHFFFAOYSA-N |
| Smiles | Cl.Cl.OC(=O)COCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=C(Cl)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Cetirizine dihydrochloride
References for Cetirizine dihydrochloride
References are publications that support the biological activity of the product.
Campoli-Richards et al (1990) Cetirizine. A review of its pharmacological properties and clinical potential in allergic rhinitis, pollen-induced asthma, and chronic urticaria. Drugs 40 762 PMID: 1981354
Snowman and Snyder (1990) Cetirizine: actions on neurotransmitter receptors. J.Allergy.Clin.Immunol. 86 1025 PMID: 1979798
Walsh et al (1991) Effects of cetirizine on human eosinophil and neutrophil activation in vitro. Int.Arch.Allergy Appl.Immunol. 95 158 PMID: 1682275
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Keywords: Cetirizine dihydrochloride, Cetirizine dihydrochloride supplier, Selective, H1, antagonists, Receptors, Histamine, histaminergic, P071, P, 071, 2577, Tocris Bioscience
4 Citations for Cetirizine dihydrochloride
Citations are publications that use Tocris products. Selected citations for Cetirizine dihydrochloride include:
Kim et al (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol 17 149 PMID: 23626477
Lenz et al (2018) Mast Cells in the Developing Brain Determine Adult Sexual Behavior. J Neurosci 38 8044 PMID: 30093566
Ito et al (2015) PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. PLoS One 11 547 PMID: 25714760
Kemp et al (2014) DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair. J Biol Chem 289 26574 PMID: 25107903
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.