Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewCI 988
Description: Potent and selective CCK2 antagonist
Alternative Names: PD 134308
Chemical Name: 4-[[(1R)-2-[[(2R)-3-(1H-indol-3-yl)-2-methyl-1-oxo-2-[[(tricyclo[3.3.1.13,7]dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]-4-oxobutanoic acid
Purity: ≥99% (HPLC)
Biological Activity for CI 988
CI 988 is a potent and selective CCK2 (CCK-B) receptor antagonist that displays ~ 1600-fold selectivity over CCK1 receptors (IC50 values are 1.7 and 2717 nM for CCK2 and CCK1 respectively). Has negligible affinity at a range of other binding sites (IC50 > 10 μM). Exhibits anxiolytic activity following oral administration.
Compound Libraries for CI 988
CI 988 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CI 988
| M. Wt | 614.73 |
| Formula | C35H42N4O6 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 130332-27-3 |
| PubChem ID | 108187 |
| InChI Key | FVQSSYMRZKLFDR-ZABPBAJSSA-N |
| Smiles | C[C@](NC(OC5C3CC(CC5C6)CC6C3)=O)(C(NC[C@@H]([C@]4=CC=CC=C4)NC(CCC(O)=O)=O)=O)CC2=CNC1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CI 988
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 61.47 | 100 |
Preparing Stock Solutions for CI 988
The following data is based on the product molecular weight 614.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.63 mL | 8.13 mL | 16.27 mL |
| 5 mM | 0.33 mL | 1.63 mL | 3.25 mL |
| 10 mM | 0.16 mL | 0.81 mL | 1.63 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for CI 988
References for CI 988
References are publications that support the biological activity of the product.
Moody et al (2001) CI-988 inhibits growth of small cell lung cancer cells. J.Pharmacol.Exp.Ther. 299 1154 PMID: 11714907
Andre et al (2005) Involvement of cholecystokininergic systems in anxiety-induced hyperalgesia in male rats: behavioral and biochemical studies. J.Neurosci. 25 7896 PMID: 16135746
Hughes et al (1990) Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proc.Natl.Acad.Sci.USA 87 6728
If you know of a relevant reference for CI 988, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: CI 988, CI 988 supplier, Potent, selective, CCK2, antagonists, Cholecystokinin2, Receptors, CI988, PD134308, PD, 134308, Receptor, 2607, Tocris Bioscience
Citations for CI 988
Citations are publications that use Tocris products.
Currently there are no citations for CI 988. Do you know of a great paper that uses CI 988 from Tocris? Please let us know.
Reviews for CI 988
There are currently no reviews for this product. Be the first to review CI 988 and earn rewards!
Have you used CI 988?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.