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Submit ReviewDantrolene, sodium salt
Description: Ca2+ release inhibitor
Chemical Name: 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione sodium salt
Purity: ≥98% (HPLC)
Biological Activity for Dantrolene, sodium salt
Inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.
Technical Data for Dantrolene, sodium salt
| M. Wt | 336.23 |
| Formula | C14H9N4NaO5 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 14663-23-1 |
| PubChem ID | 6604100 |
| InChI Key | KSRLIXGNPXAZHD-HAZZGOGXSA-M |
| Smiles | O=C([N-]3)N(CC3=O)/N=C/C1=CC=C(C2=CC=C([N+]([O-])=O)C=C2)O1.[Na+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Dantrolene, sodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.36 | 10 |
Preparing Stock Solutions for Dantrolene, sodium salt
The following data is based on the product molecular weight 336.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.74 mL | 148.71 mL | 297.42 mL |
| 0.5 mM | 5.95 mL | 29.74 mL | 59.48 mL |
| 1 mM | 2.97 mL | 14.87 mL | 29.74 mL |
| 5 mM | 0.59 mL | 2.97 mL | 5.95 mL |
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Product Datasheets for Dantrolene, sodium salt
References for Dantrolene, sodium salt
References are publications that support the biological activity of the product.
Hotchkiss and Karl (1994) Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia. Proc.Natl.Acad.Sci.U.S.A. 91 3039 PMID: 8159702
O'Mara et al (1995) Dantrolene inhibits long-term depression and depotentiation of synaptic transmission in the rat dentate gyrus. Neuroscience 68 621 PMID: 8577362
Zhao et al (2001) Dantrolene inhibition of ryanodine receptor Ca2+ release channels. J.Biol.Chem. 276 13810 PMID: 11278295
Merck Index 12 2879
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Keywords: Dantrolene, sodium salt, Dantrolene, sodium salt supplier, Ca2+, release, inhibitors, inhibits, Calcium, Signaling, Signalling, Agents, General, ryanodine, receptors, ion, channels, Ryanodine, Receptors, 0507, Tocris Bioscience
9 Citations for Dantrolene, sodium salt
Citations are publications that use Tocris products. Selected citations for Dantrolene, sodium salt include:
Wang et al (2015) Role of Na+/Ca2+ exchanger in Ca2+ homeostasis in rat suprachiasmatic nucleus neurons. J Neurophysiol 113 2114 PMID: 25568156
Efthymiou et al (2015) Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling. Int J Mol Sci 4 230 PMID: 25637190
Lin et al (2015) Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals. FEMS Immunol Med Microbiol 16 5555 PMID: 25768340
Patel et al (2009) Mobilization of calcium from intracellular stores facilitates somatodendritic DA release. J Neurosci 29 6568 PMID: 19458227
Florea et al (2017) Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma. Oncotarget 8 22876 PMID: 28206967
Agarwal et al (2017) Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron 93 587 PMID: 28132831
Battefeld et al (2019) High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling. Cell Rep 26 182 PMID: 30605675
Drdla and Sandkühler (2008) Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo. Mol Pain 4 18 PMID: 18507818
Wieland et al (2006) Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels. J Pharmacol Exp Ther 47 296 PMID: 16831218
Do you know of a great paper that uses Dantrolene, sodium salt from Tocris? Please let us know.
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Dantrolene modulates synaptic function.
By
Anonymous on 08/17/2019
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Hippocampus
Dantrolene was used to test impact of Ca2+ efflux from internal stores on neurotransmitter vesicle release in living neurons. Dantrolene, being added to intracellular solution, suppressed release of synaptic vesicles. Figure: change of a neuron electrical capacitance in response to series of electrical stimuli. Increase of electrical capacitance reflects increased number of vesicles fusing with cell membrane.
