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Submit ReviewEndoxifen
Description: Potent antiestrogen; ERα ligand
Chemical Name: (E/Z)-4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol
Purity: ≥98% (HPLC)
Biological Activity for Endoxifen
Endoxifen is an estrogen receptor α (ERα) ligand; potent antiestrogen. Metabolite of tamoxifen (Cat. No. 0999). Primary metabolite responsible for the effectiveness of tamoxifen in ER-positive breast cancer.
Technical Data for Endoxifen
| M. Wt | 373.49 |
| Formula | C25H27NO2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 110025-28-0 |
| PubChem ID | 130621 |
| InChI Key | MHJBZVSGOZTKRH-IZHYLOQSSA-N |
| Smiles | CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCNC)C=C2)\C3=CC=C(O)C=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Endoxifen
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.35 | 100 |
Preparing Stock Solutions for Endoxifen
The following data is based on the product molecular weight 373.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.68 mL | 13.39 mL | 26.77 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.35 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.68 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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Product Datasheets for Endoxifen
References for Endoxifen
References are publications that support the biological activity of the product.
Lim et al (2006) Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells. J.Pharmacol.Exp.Ther. 318 503 PMID: 16690721
Wu et al (2009) The tamox. metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor a for degradation in breast cancer cells. Cancer Res. 69 1722 PMID: 19244106
Wu et al (2011) Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen. Breast Cancer Res. 13 R27 PMID: 21392396
If you know of a relevant reference for Endoxifen, please let us know.
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Keywords: Endoxifen, Endoxifen supplier, Endoxifen, tamoxifen, metabolite, antiestrogen, ERalpha, ligands, estrogen, receptors, alpha, ERα, ERa, Estrogen, and, Related, Receptors, 3705, Tocris Bioscience
1 Citation for Endoxifen
Citations are publications that use Tocris products. Selected citations for Endoxifen include:
Maria et al (2020) Divergent Effects of Daidzein and its Metabolites on Estrogen-Induced Survival of Breast Cancer Cells. Cancers (Basel) 12 PMID: 31936631
Do you know of a great paper that uses Endoxifen from Tocris? Please let us know.
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