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Submit ReviewERB 041
Description: Potent ERβ agonist
Chemical Name: 7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol
Purity: ≥98% (HPLC)
Biological Activity for ERB 041
ERB 041 is a potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC50 values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for ERB 041
| M. Wt | 271.24 |
| Formula | C15H10FNO3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 524684-52-4 |
| PubChem ID | 5326893 |
| InChI Key | FCXYSEXZEGPLGG-DHDCSXOGSA-N |
| Smiles | C=CC1=C2C(N=C(C3=CC=C(O)C(F)=C3)O2)=CC(O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ERB 041
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.12 | 100 | |
| ethanol | 27.12 | 100 |
Preparing Stock Solutions for ERB 041
The following data is based on the product molecular weight 271.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.69 mL | 18.43 mL | 36.87 mL |
| 5 mM | 0.74 mL | 3.69 mL | 7.37 mL |
| 10 mM | 0.37 mL | 1.84 mL | 3.69 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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Product Datasheets for ERB 041
References for ERB 041
References are publications that support the biological activity of the product.
Harris et al (2003) Evaluaton of an estrogen receptor-β agonist in animal models of human disease. Endocrinology 144 4241 PMID: 14500559
Malamas et al (2004) Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem. 47 5021 PMID: 15456246
Cvoro et al (2008) Selective estrogen receptor-γ agonists repress transcription of proinflammatory genes. J.Immunol. 180 630 PMID: 18097065
If you know of a relevant reference for ERB 041, please let us know.
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Keywords: ERB 041, ERB 041 supplier, pfizer, ERB041, potent, erb, erbeta, erγ, estrogen, receptors, agonists, selective, Estrogen, and, Related, Receptors, 4276, Tocris Bioscience
2 Citations for ERB 041
Citations are publications that use Tocris products. Selected citations for ERB 041 include:
Gang et al (2021) Estrogen Receptor β Contributes to Both Hypertension and Hypothalamic Plasticity in a Mouse Model of Peri-Menopause. J Neurosci 41 5190-5205 PMID: 33941651
Cortes et al (2018) GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment. EMBO Rep. e46556 PMID: 30538117
Do you know of a great paper that uses ERB 041 from Tocris? Please let us know.
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