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Submit ReviewFerrostatin 1
Description: Selective inhibitor of erastin induced ferroptosis
Chemical Name: Ethyl 3-amino-4-(cyclohexylamino)benzoate
Purity: ≥98% (HPLC)
Biological Activity for Ferrostatin 1
Ferrostatin 1 is a selective inhibitor of erastin induced ferroptosis (EC50 = 60 nM). Specifically inhibits Ras selective lethal compound -induced death, but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Inhibits ferroptosis in cancer cells; also inhibits glutamate-induced cell death in organotypic rat brain slices. Prevents erastin induced accumulation of cytosolic and lipid reactive oxygen species.
Compound Libraries for Ferrostatin 1
Ferrostatin 1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Ferrostatin 1
| M. Wt | 262.35 |
| Formula | C15H22N2O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 347174-05-4 |
| PubChem ID | 4068248 |
| InChI Key | UJHBVMHOBZBWMX-UHFFFAOYSA-N |
| Smiles | O=C(OCC)C1=CC(N)=C(NC2CCCCC2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ferrostatin 1
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.23 | 100 | |
| ethanol | 26.23 | 100 |
Preparing Stock Solutions for Ferrostatin 1
The following data is based on the product molecular weight 262.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.81 mL | 19.06 mL | 38.12 mL |
| 5 mM | 0.76 mL | 3.81 mL | 7.62 mL |
| 10 mM | 0.38 mL | 1.91 mL | 3.81 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
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Product Datasheets for Ferrostatin 1
References for Ferrostatin 1
References are publications that support the biological activity of the product.
Dixon et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149 1060 PMID: 22632970
Louandre et al (2013) Iron-dependent cell death of hepatocellular carcinoma cells exposed to sora. Int.J.Cancer 133 1732 PMID: 23505071
Skouta et al (2014) FerroSTAT inhibit oxidative lipid damage and cell death in diverse disease models. J.Am.Chem.Soc. 136 4551 PMID: 24592866
If you know of a relevant reference for Ferrostatin 1, please let us know.
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Keywords: Ferrostatin 1, Ferrostatin 1 supplier, Selective, inhibitors, inhibits, erastin, induced, ferroptosis, RAS, selective, lethal, compound, RSL, ROS, Ferroptosis, 5180, Tocris Bioscience
1 Citation for Ferrostatin 1
Citations are publications that use Tocris products. Selected citations for Ferrostatin 1 include:
Bi et al (2019) Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death Dis 10 682 PMID: 31527591
Do you know of a great paper that uses Ferrostatin 1 from Tocris? Please let us know.
Reviews for Ferrostatin 1
Average Rating: 5 (Based on 1 Review.)
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Ferroptosis-related studies.
By
MARINA KOUTSIOUMPA on 10/13/2022
Assay Type: In Vitro
Species: Human
Combinatorial treatments of Ferrostatin 1 with other chemotherapeutic drugs were performed to elucidate the dependence of the latter on the induction of ferroptosis. Results were consistent.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Pathways for Ferrostatin 1
