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FIN 56

Cat. No. 6280 1 Citation Submit a Review Datasheet / COA / SDS
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Description: Ferroptosis activator
Chemical Name: N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (3)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for FIN 56

FIN 56 is a bifunctional inducer of ferroptosis in vitro. Activates squalene synthase (SQS) leading to coenzyme Q10 depletion. Also induces degradation of glutathione peroxidase 4 (GPX4), via acetyl-CoA carboxylase (ACC).

Compound Libraries for FIN 56

FIN 56 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for FIN 56

M. Wt 517.66
Formula C25H31N3O5S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1083162-61-1
PubChem ID 118986699
InChI Key JLCFMMIWBSZOIS-UHFFFAOYSA-N
Smiles ON=C1C2=CC(=CC=C2C2=CC=C(C=C12)S(=O)(=O)NC1CCCCC1)S(=O)(=O)NC1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FIN 56

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.77 100

Preparing Stock Solutions for FIN 56

The following data is based on the product molecular weight 517.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.66 mL 19.32 mL
5 mM 0.39 mL 1.93 mL 3.86 mL
10 mM 0.19 mL 0.97 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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References for FIN 56

References are publications that support the biological activity of the product.

Shimada et al (2016) Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat.Chem.Biol. 12 497 PMID: 27159577

Cotto-Rios and Gavathiotis (2016) Chemical genetics: Unraveling cell death mysteries. Nat.Chem.Biol. 12 470 PMID: 27315536

If you know of a relevant reference for FIN 56, please let us know.

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Keywords: FIN 56, FIN 56 supplier, FIN56, glutathione, peroxidase, 4, GPX4, activates, ferroptosis, activators, squalene, synthase, acetyl-CoA, carboxylase, ACC, Ferroptosis, Enzyme, Substrates, /, Activators, 6280, Tocris Bioscience

1 Citation for FIN 56

Citations are publications that use Tocris products. Selected citations for FIN 56 include:

Jeff et al (2020) Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis. Elife 9 PMID: 32686647

Do you know of a great paper that uses FIN 56 from Tocris? Please let us know.

Reviews for FIN 56

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Pathways for FIN 56

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.