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Flutamide

Cat. No. 4094 2 Citations Submit a Review Datasheet / COA / SDS
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Description: Non-steroidal androgen receptor antagonist
Alternative Names: SCH 13521
Chemical Name: 2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Flutamide

Flutamide is a non-steroidal antiandrogen; competitive antagonist of the androgen receptor. Blocks the biological activity of testosterone in vivo.

Compound Libraries for Flutamide

Flutamide is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Flutamide

M. Wt 276.21
Formula C11H11F3N2O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 13311-84-7
PubChem ID 3397
InChI Key MKXKFYHWDHIYRV-UHFFFAOYSA-N
Smiles CC(C)C(NC1=CC(C(F)(F)F)=C([N+]([O-])=O)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Flutamide

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.62 100
ethanol 27.62 100

Preparing Stock Solutions for Flutamide

The following data is based on the product molecular weight 276.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.1 mL 36.2 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for Flutamide

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Flutamide

References are publications that support the biological activity of the product.

Sufrin and Coffey (1976) Flutamide. Mechanism of action of a new nonsteroidal antiandrogen. Invest.Urol. 13 429 PMID: 1270239

Butcher et al (2007) Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells. Cancer Res. 67 85 PMID: 17210686

Foster et al (2011) Drug safety is a barrier to the discovery and development of new androgen receptor antagonists. Prostate 71 480 PMID: 20878947

If you know of a relevant reference for Flutamide, please let us know.

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Keywords: Flutamide, Flutamide supplier, androgen, receptors, antagonists, antiandrogen, nonsteroidal, SCH13521, chemotherapeutics, SCH, 13521, Androgen, Receptor, 4094, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Flutamide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

2 Citations for Flutamide

Citations are publications that use Tocris products. Selected citations for Flutamide include:

Y S et al (2019) Androgen Receptor-Mediated Regulation of Intracellular Calcium in Human Airway Smooth Muscle Cells. Cell Physiol Biochem 53 215-228 PMID: 31299143

Luis-Miguel et al (2020) The synthetic steroid tibolone exerts sex-specific regulation of astrocyte phagocytosis under basal conditions and after an inflammatory challenge. J Neuroinflammation 17 37 PMID: 31992325

Do you know of a great paper that uses Flutamide from Tocris? Please let us know.

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