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FPA 124

Cat. No. 2926 1 Citation Submit a Review Datasheet / COA / SDS
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Description: Akt/PKB inhibitor
Chemical Name: Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide copper complex
Datasheet
Citations (1)
Reviews
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for FPA 124

FPA 124 is an Akt/PKB inhibitor (IC50 = 100 nM) that interacts with the PH and kinase domains. Inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo.

Technical Data for FPA 124

M. Wt 381.73
Formula C11H9Cl2CuN3O2S
Storage Store at +4°C
CAS Number 902779-59-3
PubChem ID 16034833
InChI Key HZRXQEVFXXQYFS-VBPDOGLUSA-L
Smiles Cl[Cu]Cl.NC(=S)N\N=C\C1=COC2=C(C=CC=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FPA 124

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.82 10
ethanol 3.82 10

Preparing Stock Solutions for FPA 124

The following data is based on the product molecular weight 381.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.2 mL 130.98 mL 261.97 mL
0.5 mM 5.24 mL 26.2 mL 52.39 mL
1 mM 2.62 mL 13.1 mL 26.2 mL
5 mM 0.52 mL 2.62 mL 5.24 mL

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References for FPA 124

References are publications that support the biological activity of the product.

Barve et al (2006) Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. J.Med.Chem. 49 3800 PMID: 16789737

If you know of a relevant reference for FPA 124, please let us know.

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Keywords: FPA 124, FPA 124 supplier, Akt, PKB, inhibitors, inhibits, Protein, Kinases, B, FPA124, (Protein, Kinase, B), B/Akt, 2926, Tocris Bioscience

1 Citation for FPA 124

Citations are publications that use Tocris products. Selected citations for FPA 124 include:

Liddell et al (2016) Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. J Neuroinflammation 13 49 PMID: 26920699

Do you know of a great paper that uses FPA 124 from Tocris? Please let us know.

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Pathways for FPA 124

Akt Signaling Pathway

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.