Home / Pharmacology / Ion Channels / Chloride Channels / CFTR / CFTR Blockers / GlyH 101

GlyH 101

Cat. No. 5485 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Reversible, voltage-dependent CFTR chloride channel blocker
Chemical Name: N-2-Naphthalenyl-2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]glycine hydrazide
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for GlyH 101

GlyH 101 is a reversible, voltage-dependent CFTR chloride channel blocker (Ki = 4.3 μM). Inhibits forskolin-induced hyperpolarization in nasal potential differences and inhibits cholera toxin-induced intestinal fluid secretion in mice.

Technical Data for GlyH 101

M. Wt 493.15
Formula C19H15Br2N3O3
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 328541-79-3
PubChem ID 11260414
InChI Key FLGYCSPPJQJZCH-LCYFTJDESA-N
Smiles O=C(N/N=C/C3=C(O)C(Br)=C(O)C(Br)=C3)CNC2=CC1=CC=CC=C1C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GlyH 101

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.31 100

Preparing Stock Solutions for GlyH 101

The following data is based on the product molecular weight 493.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.14 mL 20.28 mL
5 mM 0.41 mL 2.03 mL 4.06 mL
10 mM 0.2 mL 1.01 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for GlyH 101

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for GlyH 101

References are publications that support the biological activity of the product.

Muanprasat et al (2004) Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J.Gen.Physiol. 124 125 PMID: 15277574

Norimatsu et al (2012) Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator. Mol.Pharmacol. 82 1042 PMID: 22923500

If you know of a relevant reference for GlyH 101, please let us know.

View Related Products by Target

View Related Products by Product Action

View all CFTR Blockers

Keywords: GlyH 101, GlyH 101 supplier, GlyH101, Cl-, chloride, channels, blockers, CFTR, cystic, fibrosis, transmembrane, conductance, regulators, voltage, dependent, 5485, Tocris Bioscience

Citations for GlyH 101

Citations are publications that use Tocris products.

Currently there are no citations for GlyH 101. Do you know of a great paper that uses GlyH 101 from Tocris? Please let us know.

Reviews for GlyH 101

There are currently no reviews for this product. Be the first to review GlyH 101 and earn rewards!

Have you used GlyH 101?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review