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GSK 4716

Cat. No. 3075 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective ERRγ and ERRβ agonist
Alternative Names: GW4716
Chemical Name: 4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for GSK 4716

GSK 4716 is a selective agonist at estrogen-related receptors ERRβ and ERRγ. Displays selectivity over ERRα and the classical estrogen receptors.

Technical Data for GSK 4716

M. Wt 282.34
Formula C17H18N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 101574-65-6
PubChem ID 5331325
InChI Key IKPPIUNQWSRCOZ-WOJGMQOQSA-N
Smiles OC1=CC=C(C(N/N=C/C2=CC=C(C(C)C)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GSK 4716

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.23 100
ethanol 28.23 100

Preparing Stock Solutions for GSK 4716

The following data is based on the product molecular weight 282.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.71 mL 35.42 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

Molarity Calculator

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Dilution Calculator

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References for GSK 4716

References are publications that support the biological activity of the product.

Zuercher et al (2005) Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRβ and ERRγ. J.Med.Chem. 48 3107 PMID: 15857113

Ariazi and Jordan (2006) Estrogen-related receptors as emerging targets in cancer and metabolic disorders. Curr.Top.Med.Chem. 6 203 PMID: 16515477

Wang et al (2006) X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J.Biol.Chem. 281 37773 PMID: 16990259

If you know of a relevant reference for GSK 4716, please let us know.

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Keywords: GSK 4716, GSK 4716 supplier, Selective, ERRγ, ERRgamma, ERRβ, ERRbeta, agonists, Estrogen, related, Receptors, GSK4716, GW4716, and, Related, 3075, Tocris Bioscience

1 Citation for GSK 4716

Citations are publications that use Tocris products. Selected citations for GSK 4716 include:

Weber et al (2014) Bisphenol A exposure during early development induces sex-specific changes in adult zebrafish social interactions. J Toxicol Environ Health A 78 50 PMID: 25424546

Do you know of a great paper that uses GSK 4716 from Tocris? Please let us know.

Reviews for GSK 4716

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Pathways for GSK 4716

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.