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Submit ReviewHS 024
Description: Highly potent MC4 receptor antagonist
Purity: ≥95% (HPLC)
Biological Activity for HS 024
HS 024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.
Technical Data for HS 024
| M. Wt | 1266.5 |
| Formula | C58H79N19O10S2 |
| Sequence |
CXRHXRWGC (Modifications: Cys-1 = N-terminal Ac, X-2 = Nle, X-5 = Nal, Cys-9 = C-terminal amide, Disulfide bridge: 1-9) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 212370-59-7 |
| PubChem ID | 25081552 |
| InChI Key | PUOCNCOPVAOMDE-LQXMKOPKSA-N |
| Smiles | CCCC[C@@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)NC(C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for HS 024
| Solubility | Soluble to 0.50 mg/ml in water |
Product Datasheets for HS 024
References for HS 024
References are publications that support the biological activity of the product.
Jonsson et al (2001) Melanocortin receptor agonist transiently increases oxygen consumption in rats. Neuroreport 12 3703 PMID: 11726778
Jonsson et al (2002) Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats. J.Endocrinol. 173 517 PMID: 12065241
Kask et al (1998) Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology 139 5006 PMID: 9832440
If you know of a relevant reference for HS 024, please let us know.
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Keywords: HS 024, HS 024 supplier, potent, MC4R, receptor, antagonists, Receptors, Melanocortin, HS024, 1832, Tocris Bioscience
2 Citations for HS 024
Citations are publications that use Tocris products. Selected citations for HS 024 include:
Simamura et al (2015) Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5. J Neurochem 10 e0123232 PMID: 25860801
Nepomuceno et al (2018) Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro. Front Pharmacol 9 157 PMID: 29599718
Do you know of a great paper that uses HS 024 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.