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IBG3

Cat. No. 8129 Submit a Review Datasheet / COA / SDS
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Description: Potent molecular glue Degrader of BRD4 and BRD2 bromodomains
Chemical Name: tert-Butyl 2-((S)-4-(4-((4'-((S)-6-(2-(tert-butoxy)-2-oxoethyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-[1,1'-biphenyl]-4-carboxamido)methyl)phenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Scientific Data Technical Data Solubility Calculators Datasheets References

Biological Activity for IBG3

IBG3 is a very potent JQ1-containing molecular glue Degrader of BET bromodomains BRD4 and BRD2 (DC50 values are 6.7 pM and 8.6 pM respectively). Induces proximity between BRD4 and DCAF16 to form a ternary complex (EC50 = 32 nM).

Scientific Data

In vitro assay Published vs Bio-Techne batch comparison for IBG3 View Larger

Published vs Bio-Techne batch comparison for IBG3. Endogenous HiBiT-BRD4 HEK293 cells were plated at a density of 20,000 cell per well in 100 µL of DMEM (10% FBS) in a white-walled 96 well plate and left overnight to adhere at 37 ºC, 5% CO2. Cells were incubated in 50 µL of 10 nM-0.1 pM of IBG3 or vehicle control (DMSO)  in Optimem (10% FBS) and left for 4 hours. Cells were then treated with HiBIT Lytic assay reagent– and plates were then read on a BMG Pherastar plate reader for luminescence detection. Data kindly provided by the Ciulli laboratory, University of Dundee.

Technical Data for IBG3

M. Wt 976.23
Formula C54H57N9O5S2
Storage Store at -20°C
PubChem ID 171037958
InChI Key MRIUQCAXSFYTQZ-YATWDLPUSA-N
Smiles CC1=C(SC2=C1C(C3=CC=C(C=C3)C4=CC=C(C=C4)C(NCC5=CC=C(C6=N[C@H](C7=NN=C(N7C8=C6C(C)=C(S8)C)C)CC(OC(C)(C)C)=O)C=C5)=O)=N[C@H](C9=NN=C(N92)C)CC(OC(C)(C)C)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for IBG3

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 97.62 100

Preparing Stock Solutions for IBG3

The following data is based on the product molecular weight 976.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.02 mL 5.12 mL 10.24 mL
5 mM 0.2 mL 1.02 mL 2.05 mL
10 mM 0.1 mL 0.51 mL 1.02 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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References for IBG3

References are publications that support the biological activity of the product.

Hsia et al (2024) Targeted protein degradation via intramolecular bivalent glues. Nature 627 204 PMID: 38383787

If you know of a relevant reference for IBG3, please let us know.

View Related Products by Target

Keywords: IBG3, IBG3 supplier, molecular, glue, degrader, degraders, degrades, BRD2, BRD4, bromodomain, bromodomains, DCAF16, induced, proximity, JQ1, Molecular, Glues, 8129, Tocris Bioscience

Citations for IBG3

Citations are publications that use Tocris products.

Currently there are no citations for IBG3. Do you know of a great paper that uses IBG3 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools