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iFSP1

Cat. No. 7162 Submit a Review Datasheet / COA / SDS
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Description: Ferroptosis suppressor protein 1 (FSP1) inhibitor; ferroptosis inducer
Chemical Name: 1-Amino-3-(4-methylphenyl)-pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for iFSP1

iFSP1 is a ferroptosis inducer. Inhibits ferroptosis suppressor protein 1 (FSP1) and induces ferroptosis in GPX4 knockout cells. Sensitizes tumor cells to RSL3 (Cat. No. 6118) -induced ferroptosis.

Technical Data for iFSP1

M. Wt 323.36
Formula C20H13N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 150651-39-1
PubChem ID 699043
InChI Key FNESYDFRCQEEKA-UHFFFAOYSA-N
Smiles CC1=CC=C(C2=C(C#N)C3=NC4=CC=CC=C4N3C(N)=C2C#N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for iFSP1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.47 20

Preparing Stock Solutions for iFSP1

The following data is based on the product molecular weight 323.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.46 mL 77.31 mL 154.63 mL
1 mM 3.09 mL 15.46 mL 30.93 mL
2 mM 1.55 mL 7.73 mL 15.46 mL
10 mM 0.31 mL 1.55 mL 3.09 mL

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References for iFSP1

References are publications that support the biological activity of the product.

Bersuker et al (2019) The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575 688 PMID: 31634900

If you know of a relevant reference for iFSP1, please let us know.

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Citations for iFSP1

Citations are publications that use Tocris products.

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