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Submit ReviewLG 100268
Description: Potent and selective RXR agonist; also activates RXR/PPARγ heterodimers
Chemical Name: 6-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)cyclopropyl]-3-pyridinecarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for LG 100268
LG 100268 is a potent and selective retinoid X receptor (RXR) agonist (EC50 = 4 nM). Displays >1000-fold selectivity for RXR over RAR. Activates RXR homodimers to induce transcriptional activation. Induces tissue transglutaminase (TGase) activity in HL-60 human promyelocytic leukemia cell line. Also activates RXR/PPARγ heterodimers.
Compound Libraries for LG 100268
LG 100268 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for LG 100268
| M. Wt | 363.49 |
| Formula | C24H29NO2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 153559-76-3 |
| PubChem ID | 3922 |
| InChI Key | SLXTWXQUEZSSTJ-UHFFFAOYSA-N |
| Smiles | CC1=C(C2(C3=CC=C(C(O)=O)C=N3)CC2)C=C4C(C(C)(CCC4(C)C)C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LG 100268
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.17 | 50 |
Preparing Stock Solutions for LG 100268
The following data is based on the product molecular weight 363.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.5 mL | 27.51 mL | 55.02 mL |
| 2.5 mM | 1.1 mL | 5.5 mL | 11 mL |
| 5 mM | 0.55 mL | 2.75 mL | 5.5 mL |
| 25 mM | 0.11 mL | 0.55 mL | 1.1 mL |
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Product Datasheets for LG 100268
References for LG 100268
References are publications that support the biological activity of the product.
Lala et al (1996) Activation of specific RXR heterodimers by an antagonist of RXR homodimers. Nature. 383 450 PMID: 8837780
Boehm et al (1995) Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells. J.Med.Chem. 38 3146 PMID: 7636877
If you know of a relevant reference for LG 100268, please let us know.
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Keywords: LG 100268, LG 100268 supplier, LG100268, Retiniod, X, receptor, RXR, agonists, activators, activates, potent, selective, Retinoid, Receptor, PPARgamma, Receptors, 5920, Tocris Bioscience
Citations for LG 100268
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.