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Submit Review[Lys5,MeLeu9,Nle10]-NKA(4-10)
Description: Selective NK2 agonist
Biological Activity for [Lys5,MeLeu9,Nle10]-NKA(4-10)
Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).
Technical Data for [Lys5,MeLeu9,Nle10]-NKA(4-10)
| M. Wt | 804 |
| Formula | C39H65N9O9 |
| Sequence |
DKFVGLX (Modifications: Leu-6 = Leu(N-methyl), X = Nle & C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 137565-28-7 |
| PubChem ID | 10417908 |
| InChI Key | FIBMQAYBIOYAKI-HLYNNXGTSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for [Lys5,MeLeu9,Nle10]-NKA(4-10)
References for [Lys5,MeLeu9,Nle10]-NKA(4-10)
References are publications that support the biological activity of the product.
Chassaing et al (1991) Selective agonists of NK-2 binding sites highly active on rat portal vein (NK-3 bioassay). Neuropeptides 19 91 PMID: 1658676
Matuszek et al (1998) An investigation of tachykinin NK2 receptor subtypes in the rat. Eur.J.Pharmacol. 352 103 PMID: 9718274
Burcher et al (2008) Tachykinin NK2 receptor and functional mechanisms in human colon: changes with indomet. and in diverticular disease and ulcerative colitis. J.Pharmacol.Exp.Ther. 324 170 PMID: 17959748
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Keywords: [Lys5,MeLeu9,Nle10]-NKA(4-10), [Lys5,MeLeu9,Nle10]-NKA(4-10) supplier, Selective, NK2, agonists, Tachykinin, Receptors, Neurokinin, Receptor, 3228, Tocris Bioscience
Citations for [Lys5,MeLeu9,Nle10]-NKA(4-10)
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Currently there are no citations for [Lys5,MeLeu9,Nle10]-NKA(4-10).
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