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Submit ReviewMegestrol Acetate
Description: Synthetic progesterone analog
Chemical Name: 17-(Acetyloxy)-6-methylpregna-4,6-diene-3,20-dione
Purity: ≥98% (HPLC)
Biological Activity for Megestrol Acetate
Megestrol Acetate is a synthetic progesterone analog. Dose-dependently inhibits growth of HepG2 cells (IC50 = 260 μM) in vitro and in vivo and reduces tumor volume. High dosages improve weight gain in tumor-bearing nude mice. Orally bioavailable.
Compound Libraries for Megestrol Acetate
Megestrol Acetate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Megestrol Acetate
| M. Wt | 384.51 |
| Formula | C24H32O4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 595-33-5 |
| PubChem ID | 11683 |
| InChI Key | RQZAXGRLVPAYTJ-GQFGMJRRSA-N |
| Smiles | [H][C@@]12CC[C@](C(C)=O)([C@]1(CC[C@]3([C@]2(C=C(C4=CC(CC[C@]34C)=O)C)[H])[H])C)OC(C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Megestrol Acetate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.23 | 50 | |
| ethanol | 7.69 | 20 |
Preparing Stock Solutions for Megestrol Acetate
The following data is based on the product molecular weight 384.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.2 mL | 26.01 mL | 52.01 mL |
| 2.5 mM | 1.04 mL | 5.2 mL | 10.4 mL |
| 5 mM | 0.52 mL | 2.6 mL | 5.2 mL |
| 25 mM | 0.1 mL | 0.52 mL | 1.04 mL |
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Product Datasheets for Megestrol Acetate
References for Megestrol Acetate
References are publications that support the biological activity of the product.
Zhang and Chow (2004) The effect of mege. acetate on growth of HepG2 cells in vitro and in vivo. Clin.Cancer.Res. 10 5226 PMID: 15297426
Tchekmedyian et al (1992) Megestrol acetate in cancer anorexia and weight loss. Cancer. 69 1268 PMID: 1739926
If you know of a relevant reference for Megestrol Acetate, please let us know.
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Keywords: Megestrol Acetate, Megestrol Acetate supplier, Megestrol, acetate, progesterone, analog, agonists, agonism, weight, gain, tumor, cancer, Progesterone, Receptor, 6285, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Megestrol acetate, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov
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