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ML 120B dihydrochloride

Cat. No. 4899 1 Review Submit a Review Datasheet / COA / SDS
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Description: Novel IKK2-selective inhibitor
Chemical Name: N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ML 120B dihydrochloride

ML 120B dihydrochloride is a novel, ATP-competitive IKK2-selective inhibitor (IC50 = 60 nM at 50 μM ATP). Exhibits no inhibition at IKK1 (EC50 >100 μM), IKKε (EC50 >100 μM) or a panel of 28 other kinases (EC50 >50 μM). Exhibits antitumor activity in lymphoma-bearing SCID mice. Demonstrates synergistic cytotoxic effects with vincristine (Cat. No. 1257).

Compound Libraries for ML 120B dihydrochloride

ML 120B dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for ML 120B dihydrochloride

M. Wt 439.72
Formula C19H15ClN4O2.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1782573-78-7
PubChem ID 90488985
InChI Key AWKOVWFBTRXQLW-UHFFFAOYSA-N
Smiles ClC1=C(OC)C(NC(C4=CC=CN=C4C)=O)=C2C(C(C=CN=C3)=C3N2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 120B dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.79 20
water 2.2 5 with gentle warming

Preparing Stock Solutions for ML 120B dihydrochloride

The following data is based on the product molecular weight 439.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.37 mL 56.85 mL 113.71 mL
1 mM 2.27 mL 11.37 mL 22.74 mL
2 mM 1.14 mL 5.69 mL 11.37 mL
10 mM 0.23 mL 1.14 mL 2.27 mL

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Product Datasheets for ML 120B dihydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for ML 120B dihydrochloride

References are publications that support the biological activity of the product.

Catley et al (2006) Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle. Mol.Pharmacol. 70 697 PMID: 16687566

Nagashima et al (2006) Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta. Blood 107 4266 PMID: 16439676

Al-Katib et al (2010) I-kappa-kinase-2 (IKK-2) inhibition potentiates vincri. cytotoxicity in non-Hodgkin's lymphoma. Mol.Cancer 9 1476 PMID: 20809973

If you know of a relevant reference for ML 120B dihydrochloride, please let us know.

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Citations for ML 120B dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for ML 120B dihydrochloride. Do you know of a great paper that uses ML 120B dihydrochloride from Tocris? Please let us know.

Reviews for ML 120B dihydrochloride

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ML 120B inhibits LPS-induced TNFa expression.
By Anonymous on 12/11/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Macrophages

RAW macrophages were incubated with 1 μM ML 120B for 30 min prior to addition of 200 ng/ml LPS for 8 h to follow TNFa mRNA expression. LPS elevated TNFa mRNA levels that was significantly inhibited by pretreatment of cells with ML 120B.

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