Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewOxytocin
Description: Involved in uterine contraction and lactation
Purity: ≥95% (HPLC)
Biological Activity for Oxytocin
Oxytocin is a neurohypophyseal peptide. Stimulates uterine contraction and lactation.
Technical Data for Oxytocin
| M. Wt | 1007.19 |
| Formula | C43H66N12O12S2 |
| Sequence |
CYIQNCPLG (Modifications: Gly-9 = C-terminal amide, disulfide bridge: 1-6) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 50-56-6 |
| PubChem ID | 439302 |
| InChI Key | XNOPRXBHLZRZKH-DSZYJQQASA-N |
| Smiles | [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)[C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Oxytocin
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Oxytocin
References for Oxytocin
References are publications that support the biological activity of the product.
Barberis and Tribolle (1996) Vasopressin and oxyt. receptors in the central nervous system. Crit.Rev.Neurobiol. 10 119 PMID: 8853957
Thibonnier et al (1998) Signal transduction pathways of the human V1-vascular V2-renal, V3-pituitary vasopressin and oxyt. receptors. Prog.Brain Res. 119 147 PMID: 10074787
If you know of a relevant reference for Oxytocin, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Oxytocin, Oxytocin supplier, Involved, uterine, contraction, lactation, OT, Receptors, agonists, Oxytocin, 1910, Tocris Bioscience
6 Citations for Oxytocin
Citations are publications that use Tocris products. Selected citations for Oxytocin include:
Xiao et al (2018) OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons. Elife 7 PMID: 29676731
Rapanelli et al (2017) Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice. Biol Psychiatry 82 194 PMID: 28347488
Nøhr et al (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int 102 105 PMID: 27916541
Spaethling et al (2014) Serotonergic neuron regulation informed by in vivo single-cell transcriptomics. Hypertension 28 771 PMID: 24192459
Brierley et al (2021) Central and peripheral GLP-1 systems independently and additively suppress eating. Nat Metab 3 258 PMID: 33589843
Ferreira et al (2019) OXT can regulate myometrial smooth muscle excitability by inhibiting the Na+ -activated K+ channel, Slo2.1. J Physiol 597 137 PMID: 30334255
Do you know of a great paper that uses Oxytocin from Tocris? Please let us know.
Reviews for Oxytocin
Average Rating: 4.7 (Based on 3 Reviews.)
Have you used Oxytocin?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Stimulation of gut smooth muscle.
By
Mohammad Alqudah on 10/19/2022
Assay Type: Ex Vivo
Species: Rat
Cell Line/Tissue: Smooth muscle
Used to stimulate gut smooth muscle contraction from rats at concentrations of 10-9 to 10-5
Works as expected..
By
Anonymous on 06/01/2020
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: Paraventricular nucleus of hypothalamus
Preincubation of slices in oxytocin (200 nM) resulted in an increase in holding current when compared to slices incubated in normal ACSF.
Applied to smooth muscle in tissue bath.
By
John Broad on 01/05/2018
Species: Rat
Applied to rat uterus and human smooth muscle
Do not freeze thaw