Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewQWF
Description: MRGPRX2 antagonist; also NK1 receptor antagonist
Purity: ≥90% (HPLC)
Biological Activity for QWF
QWF is a tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.
For more information about how QWF may be used, see our protocol:
3D Culture of Lung Alveolar CellsTechnical Data for QWF
| M. Wt | 697.78 |
| Formula | C38H43N5O8 |
| Sequence |
QWF (Modifications: Gln-1 = N-terminal Boc, Trp-2 = D-Trp(Formyl), Phe-3 = Phe-OBzl) |
| Storage | Store at -20°C |
| Purity | ≥90% (HPLC) |
| CAS Number | 126088-82-2 |
| PubChem ID | 336446954 |
| InChI Key | ZFZOHFAASQHWER-NCRUWMDKNA-N |
| Smiles | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CN(C=O)C2=CC=CC=C12)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OCC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for QWF
| Solubility | Soluble to 10 mg/ml in DMSO |
Product Datasheets for QWF
References for QWF
References are publications that support the biological activity of the product.
Hagiwara et al (1992) Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists. J.Med.Chem. 35 2015 PMID: 1375965
Azimi et al (2016) Dual action of neurokinin-1 antagonists on Mas-related GPCRs. JCI Insight. 1 e89362 PMID: 27734033
If you know of a relevant reference for QWF, please let us know.
View Related Products by Target
View Related Products by Product Action
View all Mas-Related G Protein-Coupled Receptors Antagonists
Keywords: QWF, QWF supplier, substance, P, antagonist, antagonism, NK1R, neurokinin, 1, mas-related, GPCR, X2, MRGPRX2, mast, cell, degranulation, SP, MRGX2, Mas-related, G, Protein-Coupled, Receptors, NK1, Receptor, 6642, Tocris Bioscience
2 Citations for QWF
Citations are publications that use Tocris products. Selected citations for QWF include:
Caroline L et al (2020) Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens. Immunity 53 1063-1077.e7 PMID: 33098765
Song and Shim et al (2021) Lithocholic Acid Activates Mas-Related G Protein-Coupled Receptors, Contributing to Itch in Mice Biomol Ther (Seoul) 30(1) 38 PMID: 34263729
Do you know of a great paper that uses QWF from Tocris? Please let us know.
Reviews for QWF
There are currently no reviews for this product. Be the first to review QWF and earn rewards!
Have you used QWF?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image