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Submit Review(R)-ZINC 3573
Description: MRGPRX2 agonist
Chemical Name: (3R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine
Purity: ≥98% (HPLC)
Biological Activity for (R)-ZINC 3573
(R)-ZINC 3573 is a Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist (EC50 = 0.74 μM), which displays selectivity for MRGPRX2 over 350 other GPCRs, including MRGPRX1. (R)-ZINC 3573 induces intracellular calcium release and degranulation in LAD2 mast cells in vitro.
Negative control (S)-ZINC 3573 (Cat. No. 6352) also available.
External Portal Information for (R)-ZINC 3573
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of (R)-ZINC 3573 is reviewed on chemicalprobes.org and the SGC website.
Compound Libraries for (R)-ZINC 3573
(R)-ZINC 3573 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for (R)-ZINC 3573
| M. Wt | 307.4 |
| Formula | C18H21N5 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2089389-15-9 |
| PubChem ID | 95882507 |
| InChI Key | XKBSPAZCFAIBJL-OAHLLOKOSA-N |
| Smiles | CN([C@H]1CN(C2=CC(C3=CC=CC=C3)=NC4=CC=NN24)CC1)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (R)-ZINC 3573
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 30.74 | 100 | |
| DMSO | 30.74 | 100 |
Preparing Stock Solutions for (R)-ZINC 3573
The following data is based on the product molecular weight 307.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.25 mL | 16.27 mL | 32.53 mL |
| 5 mM | 0.65 mL | 3.25 mL | 6.51 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.25 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
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Product Datasheets for (R)-ZINC 3573
References for (R)-ZINC 3573
References are publications that support the biological activity of the product.
Lansu et al (2017) In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat.Chem.Biol. 13 529 PMID: 28288109
If you know of a relevant reference for (R)-ZINC 3573, please let us know.
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Keywords: (R)-ZINC 3573, (R)-ZINC 3573 supplier, (R)-ZINC3573, ZINC3573, mas, related, g, protein, coupled, receptor, X2, agonists, MRGPRX2, mast, cell, degranulation, agonism, Mas-related, G, Protein-Coupled, Receptors, 6351, Tocris Bioscience
Citations for (R)-ZINC 3573
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