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SB 24011

Cat. No. 8010 Submit a Review Datasheet / COA / SDS
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Description: Inhibitor of STING-TRIM29 interaction; increases cellular STING levels
Chemical Name: 4-[(2R)-3,4-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]-2-(1-methylethyl)-3-oxo-1(2H)-pyrazinyl]-3-nitro-N-[[(2S)-tetrahydro-2-furanyl]methyl]benzamide
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SB 24011

SB 24011 is an inhibitor of STING-TRIM29 interaction (IC50 = 3.85 μM in vitro). SB 24011 binds to STING and inhibits TRIM29-E3 ligase interaction to increase cellular STING levels. In syngeneic mouse models, SB 24011 dose-dependently reduces tumor volume when co-admistered with cGAMP.

Technical Data for SB 24011

M. Wt 614.7
Formula C34H38N4O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1497415-41-4
PubChem ID 171038176
InChI Key UZVHJOMTRTYDKL-BHDXBOSCSA-N
Smiles CC([C@H]1N(C2=C(C=C(C=C2)C(NC[C@@H]3CCCO3)=O)[N+]([O-])=O)C=C(N(C1=O)CC4=CC=C(C=C4)O)CC5=CC=C(C=C5)OC)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SB 24011

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 61.47 100

Preparing Stock Solutions for SB 24011

The following data is based on the product molecular weight 614.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.63 mL 8.13 mL 16.27 mL
5 mM 0.33 mL 1.63 mL 3.25 mL
10 mM 0.16 mL 0.81 mL 1.63 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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References for SB 24011

References are publications that support the biological activity of the product.

Cho et al (2023) Targeted protein upregulation of STING for boosting the efficacy of immunotherapy. Angew.Chem.Int.Ed.Engl. 62 e202300978 PMID: 36827625

If you know of a relevant reference for SB 24011, please let us know.

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Keywords: SB 24011, SB 24011 supplier, SB24011, STING, TRIM29, inhibitors, inhibits, interaction, protein, dimer, dimerization, upregulation, upregulates, E3, ligase, Protein, Dimerizers, 8010, Tocris Bioscience

Citations for SB 24011

Citations are publications that use Tocris products.

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