Home / Pharmacology / Nuclear Receptors / LXR-like Receptors / LXR-like Receptor Inverse Agonists / SR 9243

SR 9243

Cat. No. 6138 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective LXR inverse agonist
Chemical Name: N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SR 9243

SR 9243 is a selective LXR inverse agonist. Exhibits no significant activity at other nuclear receptors at maximally effective concentration. Inhibits the Warburg effect and lipogenesis by down-regulation of LXR-mediated gene expression. Selectively reduces cell viability and induces apoptosis in cancer cell lines in vitro. Suppresses hepatic steatosis and inhibits growth of tumor xenografts in mice.

Technical Data for SR 9243

M. Wt 626.62
Formula C31H32BrNO4S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1613028-81-1
PubChem ID 76073169
InChI Key FYQFEJFTCLKXTQ-UHFFFAOYSA-N
Smiles CC1=CC(C)=CC(C)=C1S(N(CCC2=CC=CC(Br)=C2)CC(C=C3)=CC=C3C4=CC(S(=O)(C)=O)=CC=C4)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SR 9243

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.53 20

Preparing Stock Solutions for SR 9243

The following data is based on the product molecular weight 626.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 7.98 mL 39.9 mL 79.79 mL
1 mM 1.6 mL 7.98 mL 15.96 mL
2 mM 0.8 mL 3.99 mL 7.98 mL
10 mM 0.16 mL 0.8 mL 1.6 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for SR 9243

References are publications that support the biological activity of the product.

Flaveny et al (2015) Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis. Cancer Cell. 28 42 PMID: 26120082

If you know of a relevant reference for SR 9243, please let us know.

View Related Products by Target

View Related Products by Product Action

View all LXR-like Receptor Inverse Agonists

Keywords: SR 9243, SR 9243 supplier, SR9243, selective, LXR, inverse, agonists, agonism, lipogenesis, Warburg, effect, LXR-like, Receptors, 6138, Tocris Bioscience

Citations for SR 9243

Citations are publications that use Tocris products.

Currently there are no citations for SR 9243. Do you know of a great paper that uses SR 9243 from Tocris? Please let us know.

Reviews for SR 9243

There are currently no reviews for this product. Be the first to review SR 9243 and earn rewards!

Have you used SR 9243?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review