Home / Pharmacology / Nuclear Receptors / Estrogen and Related Receptors / Estrogen and Related Receptor Agonists / T 112

T 112

Cat. No. 7690 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Estrogen-related receptor γ agonist; promotes maturation of hiPSC-derived cardiomyocytes
Chemical Name: 2-[2-(4-Bromophenyl)-1H-benzimidazol-6-yl]-2,3-dihydro-5-(4-morpholinyl)-1H-isoindol-1-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for T 112

T 112 is an estrogen-related receptor gamma (ERRγ) agonist. Promotes maturation of hiPSC-derived cardiomyocytes. T 112 accelerates metabolic and sarcomere maturation in cardiomyocytes, as well as maturation of contractile and electrophysiological properties and ultrastructure organization, when used alone or in combination with other small molecules.

Licensing Information

Sold under license from Orizuru Therapeutics

Technical Data for T 112

M. Wt 489.37
Formula C25H21BrN4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2376876-87-6
PubChem ID 151597503
InChI Key QJTVIYLRDQROJD-UHFFFAOYSA-N
Smiles BrC1=CC=C(C2=NC3=CC=C(N4CC5=CC(N6CCOCC6)=CC=C5C4=O)C=C3N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for T 112

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.89 10

Preparing Stock Solutions for T 112

The following data is based on the product molecular weight 489.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.43 mL 102.17 mL 204.34 mL
0.5 mM 4.09 mL 20.43 mL 40.87 mL
1 mM 2.04 mL 10.22 mL 20.43 mL
5 mM 0.41 mL 2.04 mL 4.09 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for T 112

References are publications that support the biological activity of the product.

Miki et al (2021) ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes. Nat.Commun. 12 3596 PMID: 34155205

If you know of a relevant reference for T 112, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Estrogen and Related Receptor Agonists

Keywords: T 112, T 112 supplier, T112, hiPSC, human, induced, pluripotent, stem, cells, cardiomyocyte, differentiation, maturation, estrogen, receptor, gamma, agonists, agonism, ERRgamma, γ, Estrogen, and, Related, Receptors, Cardiomyocyte, Stem, Cells, 7690, Tocris Bioscience

Citations for T 112

Citations are publications that use Tocris products.

Currently there are no citations for T 112. Do you know of a great paper that uses T 112 from Tocris? Please let us know.

Reviews for T 112

There are currently no reviews for this product. Be the first to review T 112 and earn rewards!

Have you used T 112?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for T 112

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.