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Submit ReviewTaxol Janelia Fluor® 526
Description: Green-fluorescent taxol derivative; binds microtubules. Used for: microtubules imaging. Application: confocal microscopy, super resolution microscopy. Suitable for live cell imaging
Alternative Names: Janelia Fluor 526-TXL
Chemical Name: 4-((8-(((1S,2R)-3-(((2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-12-(benzoyloxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-9-yl)oxy)-2-hydroxy-3-oxo-1-phenylpropyl)amino)-8-oxooctyl)carbamoyl)-2-(3-(3,3-difluoroazetidin-1-ium-1-ylidene)-6-(3,3-difluoroazetidin-1-yl)-2,7-difluoro-3H-xanthen-9-yl)benzoate trifluoroacetate
Purity: ≥85% (HPLC)
Biological Activity for Taxol Janelia Fluor® 526
Key information: Taxol Janelia Fluor® 526 is a fluorogenic, green-fluorescent taxol derivative for direct imaging of the microtubule cytoskeleton. Suitable for live cell imaging.
Used for: direct imaging of the microtubule cytoskeleton.
Application: confocal microscopy, Super Resolution Microscopy (SRM) including STED.
Properties and Photophysical Data: Taxol Janelia Fluor® 526 is fluorogenic: it fluoresces only once bound to microtubules, enabling hassle-free no-wash experiments. Excitation and emission maxima (λ) are 531 nm and 549 nm, respectively; quantum yield = 0.87; extinction coefficient = 118,000 M-1cm-1.
Licensing Information
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus
Optical Data for Taxol Janelia Fluor® 526
| Emission Color | Yellow |
|---|---|
| λabs | 531 nm |
| λem | 549 nm |
| Extinction Coefficient (ε) | 118000 M-1cm-1 |
| Quantum Yield (φ) | 0.87 |
| Application | Confocal Microscopy, Super Resolution Microscopy (SRM), STED |
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Technical Data for Taxol Janelia Fluor® 526
| M. Wt | 1507.42 |
| Formula | C73H74F6N4O17.CF3CO2H |
| Storage | Store at -20°C |
| Purity | ≥85% (HPLC) |
| CAS Number | 2410613-93-1 |
| InChI Key | WYTXGBVNWCQFKK-SOCHEKDQSA-N |
| Smiles | [H][C@@]12C[C@@H]([C@]3(C([C@@H](C4=C([C@@H](OC([C@@H]([C@H](C5=CC=CC=C5)NC(CCCCCCCNC(C6=CC(C7=C8C=C(/C(C=C8OC9=C7C=C(C(N%10CC(F)(C%10)F)=C9)F)=[N+]%11CC(F)(C/%11)F)F)=C(C([O-])=O)C=C6)=O)=O)O)=O)C[C@@]([C@H]([C@@]3([C@]1(OC(C)=O)CO2)[H])OC(C%12=CC=CC=C%12)=O)(C4(C)C)O)C)O)=O)C)O.O=C(O[H])C(F)(F)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Taxol Janelia Fluor® 526
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.07 | 10 |
Preparing Stock Solutions for Taxol Janelia Fluor® 526
The following data is based on the product molecular weight 1507.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 6.63 mL | 33.17 mL | 66.34 mL |
| 0.5 mM | 1.33 mL | 6.63 mL | 13.27 mL |
| 1 mM | 0.66 mL | 3.32 mL | 6.63 mL |
| 5 mM | 0.13 mL | 0.66 mL | 1.33 mL |
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Product Datasheets for Taxol Janelia Fluor® 526
References for Taxol Janelia Fluor® 526
References are publications that support the biological activity of the product.
Zheng et al (2019) Rational design of fluorogenic and spontaneously blinking labels for super-resolution imaging. ACS Cent.Sci. 5 1602 PMID: 31572787
If you know of a relevant reference for Taxol Janelia Fluor® 526, please let us know.
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Keywords: Taxol Janelia Fluor 526, Taxol Janelia Fluor 526 supplier, Fluorogenic, green, fluorescent, taxol, microtubule, cytoskeleton, stains, probes, dyes, Janelia, Fluor, 526-TXL, Microtubule, Probes, 7315, Tocris Bioscience
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